University of Groningen
Replication-stress induced mitotic aberrancies in cancer biology Schoonen, Pepijn Matthijs
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2019
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Schoonen, P. M. (2019). Replication-stress induced mitotic aberrancies in cancer biology. Rijksuniversiteit Groningen.
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Replication stress-induced mitotic
aberrancies in cancer biology
The studies described in this thesis were performed at the Department of Medical Oncology of the University Medical Center Groningen, The Netherlands.
Printing of this thesis was financially supported by University of Groningen, UMCG Graduate School of Medical Sciences en stichting Werkgroep Interne Oncologie
ISBN: 9789403416311
Cover and lay-out design: G. Berger
Printing: Ipskamp Printing BV, Enschede Copyright © 2019, P. M. Schoonen
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means without permission of the author
Replication stress-induced mitotic aberrancies in cancer biology
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus Prof. Dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 22 mei 2019 om 14.30
door
Pepijn Matthijs Schoonen geboren op 27 november 1989
te Groningen
Promotor
Prof. Dr. M.A.T.M. van Vugt Co-promotor
Prof. Dr. F. Foijer
Beoordelingscommissie
Prof. Dr. S. de Jong
Prof. Dr. C.F. Calkhoven
Prof. Dr. A. de Bruin
Voor pap
Paranimfen
Max Nederkoorn
Yannick Kok
CONTENTS
Chapter 1 General Introduction p.9
Chapter 2 Replication Stress: Driver and therapeutic target in genomically instable cancers
(Advances in Protein Chemistry and Structural Biology, 2019) p.15
Chapter 3 Progression through mitosis promotes PARP inhibitor- induced cytotoxicity in homologous recombination- deficient cancer cells
(Nature Communications, 2017)
p.45
Chapter 4 ATR inhibition promotes PARP inhibitor-induced mitotic aberrancies and cytotoxicity in BRCA2-deficient cancer cells through premature mitotic entry
(Submitted)
p.77
Chapter 5 Overexpression of Cyclin E1 or Cdc25a leads to replication stress, mitotic aberrancies and increased sensitivity to replication checkpoint inhibitors (Submitted)
p.97
Chapter 6 Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability (Developmental Cell, 2015)
p.115
Chapter 7 Summary, discussion and future perspectives
(Adapted from Molecular & Cellular Oncology, 2017) p.139 Appendices
Nederlandse samenvatting Dankwoord
Over de auteur Publicaties
p.151
