University of Groningen
Clinical advances in musculoskeletal imaging: spondylodiscitis and pediatric oncology
Kasalak, Ömer
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Publication date: 2019
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Kasalak, Ö. (2019). Clinical advances in musculoskeletal imaging: spondylodiscitis and pediatric oncology. University of Groningen.
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Clinical advances in
musculoskeletal imaging:
spondylodiscitis and pediatric oncology
Clinical advances in musculoskeletal imaging: spondylodiscitis and pediatric oncology Thesis, Groningen University, The Netherlands
© Ömer Kasalak, 2018
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without permission in writing from the author. The copyright of the articles that have been published or have been accepted for publication has been transferred to the respective journals.
ISBN/EAN: ...-..-...-....-.
Printed by: Gildeprint Drukkerijen B.V., Enschede Layout: Roy Sanders
Clinical advances in
musculoskeletal imaging:
spondylodiscitis and pediatric oncology
Proefschrift
ter verkrijging van de graad doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 23 Januari 2019 om 14:30 uur
door
Ömer Kasalak
geboren op 18 april 1978 te Izmir
Promotor Prof. dr. R.A.J.O. Dierckx
Copromotores Dr. T.C. Kwee Dr. P.C. Jutte
Beoordelingscommissie Prof. dr. S.K. Bulstra Prof. dr. C. van Kuijck Prof. dr. K. Verstraete
Printing of this thesis was financially supported by: Bracco Imaging, Pfizer BV, Mermaid Medical BV, Bayer BV.
Contents
Chapter 1 General introduction 9
PART I: Spondylodiscitis
Chapter 2 CT-guided biopsy in suspected spondylodiscitis: microbiological yield, impact on antimicrobial treatment, and relationship with outcome
25
Chapter 3 Culture yield of repeat percutaneous image-guided biopsy after a negative initial biopsy in suspected spondylodiscitis: a systematic review
43
PART II: Pediatric oncology
Chapter 4 Diagnostic value of MRI signs in differentiating Ewing sarcoma from osteomyelitis
61
Chapter 5 CT-guided bone biopsies with indeterminate results in pediatric patients
79
Chapter 6 Primary tumor volume measurements in Ewing sarcoma: MRI inter- and intraobserver variability and comparison with FDG-PET
99
Chapter 7 Can FDG-PET/CT replace blind bone marrow biopsy of the posterior iliac crest in Ewing sarcoma?
117
Chapter 8 Surveillance MRI for the detection of locally recurrent Ewing sarcoma seems futile
129
Chapter 9 General discussion 143
Chapter 10 Summary 157
Nederlandse samenvatting 161
Chapter 11 Dankwoord 165
Curriculum vitae 169
