University of Groningen
Delivery of biologicals van Dijk, Fransien
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Publication date: 2018
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van Dijk, F. (2018). Delivery of biologicals: Sustained release of cell-specific proteins in fibrosis. Rijksuniversiteit Groningen.
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Delivery of biologicals
Sustained release of cell-specific proteins in fibrosis
The work described in this thesis was performed at the Groningen Research Institute of Pharmacy, department of Pharmacokinetics, Toxicology & Targeting and department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands. The research project was financially supported by a grant from the Netherlands Institute of Regenerative Medicine (NIRM) and a grant from NanoNext.NL (program 03.10).
Printing of this thesis was financially supported by the University of Groningen, LinXis BV, InnoCore Pharmaceuticals and BiOrion Technologies BV.
Delivery of biologicals
Sustained release of cell-specific proteins in fibrosis
© Copyright 2018 by Fransien van Dijk. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without prior permission of the author.
ISBN (printed version): 978-94-034-0509-4 ISBN (electronic version): 978-94-034-0508-7 Cover design: Jakko de Jong & Fransien van Dijk Lay-out: Fransien van Dijk
Delivery of biologicals
Sustained release of cell-specific proteins in fibrosis
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op vrijdag 23 maart 2018 om 11:00 uur
door
Fransien van Dijk
geboren op 21 oktober 1989 te Groningen
Promotores Prof. dr. K. Poelstra Prof. dr. P. Olinga Copromotores Dr. L. Beljaars Dr. W.L.J. Hinrichs Beoordelingscommissie Prof. dr. K.N. Faber Prof. dr. R. Gosens Prof. dr. J. Trebicka
Paranymphs
Eduard Post Hester Hoving
Dit proefschrift is opgedragen aan mijn Oma Sien
‘’Anyone who stops learning is old, whether at twenty or eighty. Anyone who keeps learning stays young.’’ - Henry Ford
Table of contents
Chapter 1 Introduction and aim of the thesis 10
Chapter 2 Targeted therapies in liver fibrosis: combining the best parts of 16 platelet-derived growth factor BB and interferon gamma
Chapter 3 Steering therapeutic proteins: the mechanism of action of mimetic 48 interferon gamma delivered to the disease-induced PDGFβ-receptor
Chapter 4 Polymeric microspheres for the sustained release of a protein-based 74 drug carrier targeting the PDGFβ-receptor in the fibrotic kidney
Chapter 5 Pharmacokinetics of a sustained release formulation of 104
PDGFβ-receptor directed carrier proteins to target the fibrotic liver
Chapter 6 The antifibrotic potential of a sustained release formulation of a 128 PDGFβ-receptor targeted rho kinase inhibitor
Chapter 7 Summary and general discussion 154
Chapter 8 Nederlandse samenvatting 172
Dankwoord 177
Curriculum vitae 181
