The handle http://hdl.handle.net/1887/25491 holds various files of this Leiden University dissertation
Author: Vorst, Joost van der
Title: Near-infrared fluorescence-guided surgery : pre-clinical validation and clinical translation
Issue Date: 2014-05-01
Near-infrared fluorescence-guided surgery
Pre-clinical validation and clinical translation
Joost van der Vorst
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The author of this thesis is a MD-medical research trainee funded by The Netherlands Organisation for Health Research and Development (grant nr. 92003593). The research described in this thesis was financially supported by the Center for Translational Molecular Medicine (CTMM, DeCoDe and MUSIS projects), the Dutch Cancer Society (UL 2010-4732), Foundation “Michaël van Vloten”, Foundation “De Drie Lichten”, Leiden University Fund (LUF).
Financial support by Krijnen Medical, Amgen, Percuros, Chipsoft, PerkinElmer,
Near-infrared fluorescence-guided surgery
Pre-clinical validation and clinical translation
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 1 mei 2014
klokke 15:00 uur
door
Joost Renier van der Vorst
geboren te Geldrop in 1984
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Prof. dr. B.P.F. Lelieveldt Prof. dr. V.T.H.B.M. Smit
Prof. dr. C.H.C. Dejong (Universiteit van Maastricht)
CONTENTS
Chapter 1 General introduction and outline of thesis 9 Part I: Pre-clinical validation of near-infrared fluorescence
guided surgery
19
Chapter 2 Near-infrared fluorescence imaging of liver metastases in rats using indocyanine green
21
Chapter 3 Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody
35
Chapter 4 Near-infrared fluorescence imaging of both colorectal cancer and ureters using a low-dose integrin targeted probe
57
Part II: Clinical translation: Sentinel lymph node imaging 73 Chapter 5 Optimization of near-infrared fluorescent sentinel lymph
node mapping for vulvar cancer
75
Chapter 6 Optimization of near-infrared fluorescent sentinel lymph node mapping in cervical cancer patients
87
Chapter 7 Randomized comparison of near-infrared fluorescence lymphatic tracers for sentinel lymph node mapping of cervical cancer
101
Chapter 8 Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma
115
Chapter 9 Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients.
131
Chapter 10 Randomized comparison of near-infrared fluorescence imaging using indocyanine green and 99mtechnetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients
141
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parathyroid adenomas using low-dose methylene blue Chapter 14 Near-infrared fluorescence imaging of a solitary fibrous tumor
of the pancreas using methylene blue
205
Part IV 215
Chapter 15 Summary and Future Perspectives 217
Nederlandse samenvatting 230
List of Publications 235
Curriculum Vitae 240
Dankwoord 241
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