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The handle http://hdl.handle.net/1887/22976 holds various files of this Leiden University dissertation

Author: Hua Zhu

Title: Environmental and metabolomic study of antibiotic production by actinomycetes

Issue Date: 2014-01-09

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Environmental and Metabolomic Study of Antibiotic Production by Actinomycetes

PROEFSCHRIFT

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op donderdag 9 januari 2014

klokke 10:00 uur

door

Hua Zhu

朱华

geboren te Suide, Shaanxi Province, China

in 1983

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PROMOTIECOMMISSIE

Promotor: Prof. dr. G.P. van Wezel

Overige leden: Prof. dr. C. J. ten Cate Prof. dr. M. Jaspars

Prof. dr. P. G. L. Klinkhamer Prof. dr. J. M. Raaijmakers Dr. Y. H. Choi

Printed by Smart Printing Solutions, Gouda, the Netherlands

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“The best way out is always through”

- Robert Frost

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This research was supported by a PhD fellowship from the China Scholarship Council.

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TABLE OF CONTENTS

1

7

31

51

77

97

119

141 148

153 170 171 Chapter 1

Chapter 2

Chapter 3

Chapter 4

Chapter 5

Chapter 6

Chapter 7

Chapter 8

References Curriculum Vitae List of Publications

General Introduction

Triggers and Cues that Activate Antibiotic Production by Actinomycetes

A New Collection of Actinomycetes Isolated from Himalaya and Qinling Mountain Soils as Source of Novel Bioactive Compounds

Induction of Antimicrobial Compounds with Efficacy against ESKAPE Pathogens using Specific Culturing Conditions

Antibiotic Production and Time-point Analysis in Streptomyces MBT76 aided by NMR-based Metabolic Monitoring

Application of NMR-based Metabolomics and Proteomics for the Analysis of Secondary Metabolite Production by Streptomyces sp. MBT70

Antimicrobial Effect of Volatile Organic Compounds Released by Metabolically Diverse Actinomycetes

General Discussion

Nederlandse Samenvatting

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