Timing of surgery for sciatica
Peul, W.C.
Citation
Peul, W. C. (2008, April 10). Timing of surgery for sciatica. Retrieved from https://hdl.handle.net/1887/12689
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12689
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Timing of Surgery for Sciatica
Wilco C. Peul
ISBN: 978-90-6464-221-0
Designed by: Grafisch Bureau Christine van der Ven, Voorschoten Cover design: Bart Blom en Dick Bensdorp, Leiden
Cover photo: “Tres Gracias” by Jacopo da Pontormo, Uffizi, Firenze Printed by: Grafische Producties, Universitair Facilitair Bedrijf, Leiden
The study presented in this thesis was performed at the departments of Neursosurgery, Medical Decision Making and Medical Statistics of the Leiden University Medical Center.The study was funded by a grant from the Health Care Efficiency Research program of the Netherlands Organization for Health Research and Development (ZonMw).
Financial support for the printing of this thesis was generously provided by Medtronic Trading, Biomet, Stryker Spine, InSpine, Braun Medical, Promedics Medical Systems, Baxter, Depuy Spine, Siemens and Zeiss
© 2008 W.C. Peul, Leiden, The Netherlands
All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, elecrtonic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission from the copyright owner.
Timing of Surgery for Sciatica
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 10 april 2008
klokke 16.15 uur
door
Wilco C. Peul
geboren te Rotterdam in 1963
P
ROMOTIECOMMISSIE:
Promotores: Prof.dr. R.T.W.M. Thomeer
Prof.dr. B.W. Koes (Erasmus Universiteit Rotterdam) Co-promotor: Dr. R. Brand
Referent: Prof. M.G. Fehlings, MD, PhD, FRCSC (University of Toronto)
Overige leden: Prof.dr. C.J.J. Avezaat (Erasmus Universiteit Rotterdam) Prof.dr. M.W. van Tulder (Vrije Universiteit van Amsterdam) Prof.dr. F.R. Rosendaal
Prof.dr. J. Stam (Universiteit van Amsterdam) Prof. dr. R.G.H.H. Nelissen
Aan Erica, Olivier, Cylemarijne en Roderick
C
ONTENTSChapter 1 Introduction and Outline Thesis
Chapter 2 Review of Literature
Diagnosis and treatment of sciatica BMJ 2007; 334(7607):1313-1317
Chapter 3 Design of “The Sciatica Trial”
Prolonged conservative treatment or ‘early’ surgery in sciatica caused by a lumbar disk herniation: rationale and design of a randomized trial
BMC-Musculoskeletal-Disorders2005;6:8
Chapter 4 One year results of randomized trial
Surgery versus Prolonged Conservative Treatment for Sciatica New England J of Medicine Vol 356(22)()(pp 2245-2256), 2007
Chapter 5 Cost utility results of trial
Cost-utility analysis of prolonged conservative care versus early surgery in patients with sciatica caused by lumbar disk herniation Submitted for publication
Chapter 6 Subgroup analysis of “The Sciatica Trial”
Subgroup analysis of a randomized trial to evaluate timing of surgery for sciatica
Submitted for publication
Chapter 7 Can we predict surgery for sciatica?
Improving prediction of “inevitable” surgery during non-surgical treatment of sciatica
Submitted for publication
Chapter 8 Gender and Sciatica
Influence of gender on outcome of sciatica; a post-hoc analysis of a randomized trial
Submitted for publication
9 21
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49
65
77
91
101
Chapter 9 Two year results of randomized trial
Timing of surgery for sciatica; 2-year results of a randomized controlled trial
Submitted for publication
Chapter 10 Synthesis and general discussion Chapter 11 Summary
Nederlandse samenvatting Reference list
Curriculum Vitae List of Publications Acknowledgements Appendix
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135 147
153 159 171 173 176 176
