Citation
Jorritsma-Smit, A. (2008, September 4). Immunotherapy of melanoma : toward clinical application. Retrieved from https://hdl.handle.net/1887/13085
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13085
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Immunotherapy of melanoma:
towards clinical application
Immunotherapy of melanoma:
towards clinical application
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 4 september 2008
klokke 13.45 uur
door
Annelies Jorritsma-Smit
geboren te Groningen
in 1977
Referent: Prof. Dr. M. Theobald (Universiteit van Utrecht)
Overige leden: Prof. E.A.J.M. Goulmy
Prof. C. Melief
Prof. W.E. Fibbe
Dr. B. Nuijen (NKI-AvL/Slotervaart Ziekenhuis)
Voor mijn ouders, voor Rutger & Doeke
The studies described in this thesis were performed at the Department of Immunology at the Netherlands Cancer Institute (NKI), Amsterdam.
This study was financially supported by the Dutch Cancer Society (KWF grant 2001-2417) and by ZonMW grant 4310005 .
The printing of this thesis was financially supported by the J.E. Jurriaanse Stichting and the Dutch Cancer Society.
The cover photo was taken at the National Pharmaceutical Museum in Gouda, the Netherlands, by Rutger Smit.
Contents
Chapter 1: Introduction 9
Chapter 2: A rapid and potent DNA vaccination strategy defined by in vivo 19 monitoring of antigen expression.
Nature Med. 2005;11(8):899-904
Chapter 3: Skewing the T-cell repertoire by combined DNA vaccination, 27 host conditioning, and adoptive transfer.
Cancer Res. 2008;68:2455-2462
Chapter 4: Human telomerase reverse transcriptase-transduced human 37 cytotoxic T cells suppress the growth of human melanoma in
immunodeficient mice.
Cancer Res. 2004 Mar 15;64(6):2153-61.
Chapter 5: Requirements for effective anti-tumor responses of TCR 49
transduced T cells
Submitted for publication
Chapter 6: Selecting highly affine and well-expressed TCRs for gene 69
therapy of melanoma.
Blood 2007;110:3564-3572
Chapter 7: Discussion 81
Summary 99
Nederlandse samenvatting 101
Curriculum Vitae 105
List of publications 107
