• No results found

University of Groningen Towards in vivo application of oxygen-releasing microspheres for enhancing bone regeneration Buizer, Arina

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen Towards in vivo application of oxygen-releasing microspheres for enhancing bone regeneration Buizer, Arina"

Copied!
7
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Towards in vivo application of oxygen-releasing microspheres for enhancing bone

regeneration

Buizer, Arina

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Buizer, A. (2018). Towards in vivo application of oxygen-releasing microspheres for enhancing bone

regeneration. Rijksuniversiteit Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

Towards in vivo application

of oxygen-releasing

microspheres for enhancing

bone regeneration

(3)

ISBN 978-94-034-0278-9 (printed version) ISBN 978-94-034-0277-2 (electronic version) Author A.T. Buizer

Cover Marleen Buizer

Lay-out Christiaan Ruiter - christiaanruiter.nl Printed by Print Service Ede

Het afdrukken van dit proefschrift werd mede mogelijk gemaakt door: De Nederlandse Orthopaedische Vereniging Universitair Medisch Centrum Groningen Stichting Anna Fonds/NOREF

© 2018, A.T. Buizer, Groningen, The Netherlands

All rights reserved. No part of this publication may be reproduced or transmitted in any form by any means, electronical, or mechanical, including photocopy, recording or any information storage or retrieval system, without the prior written permission of the copyright owner.

(4)

Towards in vivo application

of oxygen-releasing

microspheres for enhancing

bone regeneration

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties

De openbare verdediging zal plaatsvinden op

10 januari 2018 om 16.15 uur

door

Arina Tjitske Buizer

geboren op 17 maart 1982

(5)

Promotores

Prof. dr. S.K. Bulstra

Prof. dr. A.G. Veldhuizen

Co-promotor

Dr. R. Kuijer

Beoordelingscommissie

Prof. dr. R.A. Bank

Prof. dr. J. de Boer

Prof. dr. J.A.N. Verhaar

(6)

Contents

Chapter 1

7

Introduction

Chapter 2

27

Static versus vacuum cell seeding on high and low porosity ceramic

scaffolds

Chapter 3

47

The balance between proliferation and transcription of angiogenic factors of

mesenchymal stem cells in hypoxia

Chapter 4

67

Oxygen-releasing poly (trimethylene carbonate) microspheres for tissue

engineering applications

Chapter 5

85

Biocompatibility of poly (trimethylene carbonate)-calcium peroxide

microspheres

Chapter 6

101

Proof of principle of oxygen-releasing poly (trimethylene carbonate)

microspheres

Chapter 7

115

General discussion

Summary

131

Samenvatting

137

Samenvatting voor niet-deskundigen

145

Dankwoord

151

Publications and presentations

157

(7)

Referenties

GERELATEERDE DOCUMENTEN

four groups, which are the application of growth factors on a scaffold material, co- seeding or co-culturing of endothelial precursor cells (EPC) and bone precursor cells (BPC),

On high porosity scaffolds, the absolute number of live cells adherent to the scaffolds was highest if the static seeding technique was used.. On low porosity scaffolds, the

When human mesenchymal stem cells (hMSCs) encounter hypoxic conditions, they show higher cell proliferation than at ambient oxygen levels.. However, when hMSCs are exposed

Figure 6 represents the viability data of the hMSCs cultured in the presence of PTMC microspheres and oxygen delivering PTMC-CaO 2 composite microspheres determined using

The lower cell viability of L929 cells upon exposure to 100% and 75% concentrations of the PTMC-CaO 2 microsphere extract may be explained by the presence of hydrogen peroxide..

implanted films made out of a composite of poly (D,L-lactide-co-glycolide) (PLGA) and sodium percarbonate under random pattern devascularized flaps in mice and found that two

Human mesenchymal stem cells (hMSCs) are easy to harvest in fair amounts and have the capacity to form bone, so therefore this type of cell is frequently used for regeneration of

On high porosity scaffolds, however, the static cell seeding technique resulted in more homogeneous cell seeding and higher numbers of cells adherent to the scaffold than the