University of Groningen
Biodegradable implants for the biphasic pulsatile delivery of antigens
Beugeling, Max
DOI:
10.33612/diss.134204081
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Beugeling, M. (2020). Biodegradable implants for the biphasic pulsatile delivery of antigens: Toward
single-injection vaccines. University of Groningen. https://doi.org/10.33612/diss.134204081
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547040-L-sub02-st-Beugeling 547040-L-sub02-st-Beugeling 547040-L-sub02-st-Beugeling
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Propositions belonging to the thesis
The ph ysical mixtur e c oncept is an in teresting approach for biodegradable implants with a biphasic pulsa tile release of bac terial polysaccharide-based antigens. ( This thesis). Biodegradable injectable micro-tubes are promising devices for implants with a biphasic pulsatile r elease of protein-based an
tigens. (This thesis ). The lag time prior to the delayed release of the implants based on the ph ysical mixture concept and on the cor e-shell c oncept can easily be adjusted by
changing the lactic:gly colic acid r atio of the applied polymer
. (This thesis ). The obser ved release profiles for small molecule drugs fr om poly(DL -lactic- co-glycolic acid) (PL GA)-based implan ts are not necessarily pr edictiv e for comple x macromolecules , such as proteins. ( This thesis). The gr eatest challenge in the developmen t of PLG A-based implan ts tha t mimic a prime-boost administr ation regime, is to obtain a delayed release of the booster dose of protein-based an tigens in their nativ
e conf ormation. ( This thesis). Pulmonar y administr ation of dr y powder subunit-based respir ator y syncy tial virus vaccines , based on stabiliz ed pr e-fusion pr otein, should be explor ed. (This thesis). When the CO VID-19 pandemic ends , healthcar e pr ofessionals should con tinue not to shak e hands with their patien
ts. ‘Science can ’t change the world on its own, the world needs to be willing to change.’ – E. Morr a. You snooz e, you lose win. Good enough is often better than per fec
t.
Biodegradable implants for
the biphasic pulsatile delivery
of antigens
ard single-injec
Tow
tion vaccines
Max Beugeling
1. 2. 3. 4. 5. 6. 7. 8. 9.10.
Propositions belonging to the thesis
The physical mixture concept is an interesting approach for biodegradable implants with a biphasic pulsatile release of bacterial polysaccharide-based antigens. (This thesis).
Biodegradable injectable micro-tubes are promising devices for implants with a biphasic pulsatile release of protein-based antigens. (This thesis).
The lag time prior to the delayed release of the implants based on the physical mixture concept and on the core-shell concept can easily be adjusted by changing the lactic:glycolic acid ratio of the applied polymer. (This thesis). The observed release profiles for small molecule drugs from poly(DL-lactic-co-glycolic acid) (PLGA)-based implants are not necessarily predictive for complex macromolecules, such as proteins. (This thesis).
The greatest challenge in the development of PLGA-based implants that mimic a prime-boost administration regime, is to obtain a delayed release of the booster dose of protein-based antigens in their native conformation. (This thesis). Pulmonary administration of dry powder subunit-based respiratory syncytial virus vaccines, based on stabilized pre-fusion protein, should be explored. (This thesis).
When the COVID-19 pandemic ends, healthcare professionals should continue not to shake hands with their patients.
‘Science can’t change the world on its own, the world needs to be willing to change.’ – E. Morra.
You snooze, you lose win.
Good enough is often better than perfect.
