University of Groningen
Early onset sepsis in Suriname
Zonneveld, Rens
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2017
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Zonneveld, R. (2017). Early onset sepsis in Suriname: Epidemiology, Pathophysiology and Novel Diagnostic Concepts. Rijksuniversiteit Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Early Onset Sepsis in Suriname
Epidemiology, Pathophysiology, and Novel Diagnostic Concepts
ISBN (printed): 978-94-034-0256-7 ISBN (digital): 978-94-034-0257-4 Cover design: Frans Mettes
Lay-out and Printing: Off Page, Amsterdam © 2017, Rens Zonneveld
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without permission of the author.
Financial support for the research in this thesis is greatly acknowledged. The following institutes and organisations provided funding for completion and printing of this thesis:
Stichting ‘De Drie Lichten’.
Early Onset Sepsis in Suriname
Epidemiology, Pathophysiology, and Novel Diagnostic Concepts
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 11 december 2017 om 16.15 uur
door
Rens Zonneveld
geboren op 8 april 1983 te Breda
Early Onset Sepsis in Suriname
Epidemiology, Pathophysiology, and Novel Diagnostic Concepts
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 11 december 2017 om 16.15 uur
door
Rens Zonneveld
geboren op 8 april 1983 te Breda
Promotor Prof. dr. G. Molema Copromotores Dr. F.B. Plötz Dr. M. van Meurs Beoordelingscommissie Prof. dr. J.M. Smit Prof. dr. J.B. van Woensel Prof. dr. J.G. Zijlstra
TABLE OF CONTENTS
Chapter 1 General Introduction and Thesis Outline 7
Part I Epidemiology of Early Onset Sepsis in Suriname 23 Chapter 2 Improved Referral and Survival of Newborns after Scaling Up of
Intensive Care in Suriname 27 BMC Pediatrics, Accepted for Publication
Part II Prediction of Early Onset Sepsis 47 Chapter 3 Association between Early Onset Sepsis Calculator and
Infection Parameters for Newborns with Suspected Early Onset Sepsis 51 J Clin Neonatol 2017, 6:159-62
Chapter 4 Immature-to-total-granulocyte Ratio as a Guide for Antibiotic Treatment in Suspected Early Onset Sepsis in Surinamese Newborns 59 Submitted
Part III The Vascular Pathophysiology of Early Onset Sepsis 71 Chapter 5 Soluble Adhesion Molecules as Markers for Sepsis and the Potential
Pathophysiological Discrepancy in Neonates, Children and Adults 75 Critical Care 2014, 18:204
Chapter 6 Early Onset Sepsis in Surinamese Newborns is Not Associated with Elevated Serum Levels of Endothelial Cell Adhesion Molecules and
Their Shedding Enzymes 99
Submitted
Chapter 7 Low Serum Angiopoietin-1, high Angiopoietin-2, and high Ang-2/Ang-1
Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns 119 Shock 2017, May 22
Chapter 8 Analyzing Neutrophil Morphology, Mechanics, and Motility in Sepsis:
Options and Challenges for Novel Bedside Technologies 133 Critical Care Medicine 2016, 44:218-28
Chapter 9 Summary & Future Perspectives 157
Appendices 169
Appendix I Letter to the editor Critical Care (Critical Care 2016, 20:235-36.) 171 Appendix II Samenvatting (Summary in Dutch) 174
Appendix III Dankwoord 176
Appendix IV List of Publications 180
Appendix V Curriculum Vitae 182
Promotor Prof. dr. G. Molema Copromotores Dr. F.B. Plötz Dr. M. van Meurs Beoordelingscommissie Prof. dr. J.M. Smit Prof. dr. J.B. van Woensel Prof. dr. J.G. Zijlstra
