University of Groningen
Molecular imaging on the move
Bensch, Frederike
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Publication date: 2019
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Bensch, F. (2019). Molecular imaging on the move: From feasibility to contribution in clinical questions. University of Groningen.
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Molecular iMaging on the Move
From feasibility to contribution in clinical questions
Frederike Bensch
Printing of this thesis was financially supported by the Dutch Cancer Society and the Stichting Werkgroep Interne Oncologie, UMCG.
cover Joke Schepers | www.jokeschepers.exto.nl
Layout Renate Siebes | Proefschrift.nu
Printed by Proefschriftmaken.nl isBn 978-94-90791-68-1
© 2018 Frederike Bensch
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronically, mechanically, by photo-copying, recording or otherwise, without the prior written permission of the author.
Molecular imaging on the move
From feasibility to contribution in clinical questions
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 18 maart 2019 om 12.45 uur
door
Frederike Bensch
geboren op 26 augustus 1985 te Hagenow, Duitsland
Promotor
Prof. dr. E.G.E. de Vries
Copromotor
Dr. C.P. Schröder
Beoordelingscommissie
Prof. dr. G.M. van Dam Prof. dr. H.W. Nijman Prof. dr. O. Boerman
Paranimfen
Titia Lamberts Niek Westerink
Chapter 1 General introduction 11
Chapter 2 Molecular imaging for monitoring treatment response in breast cancer patients
Eur. J. Pharmacol. 717, 2-11 (2013).
19
Chapter 3 89Zr-lumretuzumab PET imaging before and during HER3 antibody lumretuzumab treatment in patients with solid tumors
Clin. Cancer Res. 23, 6128-6137 (2017).
43
Chapter 4 TGF-β antibody uptake in recurrent high grade glioma imaged with 89Zr-fresolimumab PET
J. Nucl. Med. 56, 1310-1314 (2015).
73
Chapter 5 Comparative biodistribution analysis across four different 89 Zr-monoclonal antibody tracers – the first step towards an imaging warehouse
Theranostics 8, 4295-4304 (2018).
87
Chapter 6 Clinical 89Zr-atezolizumab imaging as a PD-L1 biomarker in cancer patients
Nat. Med. 24, 1852-1858 (2018).
115
Chapter 7 89Zr-trastuzumab PET supports clinical decision making in breast cancer patients, when HER2 status cannot be determined by standard work up
Eur. J. Nucl. Med. Mol. Imaging 45, 2300-2306 (2018).
155
Chapter 8 Summary and future perspective 177
Chapter 9 Nederlandse samenvatting (Dutch summary) 187
Chapter 10 Deutsche Zusammenfassung (German summary) 195
Curriculum vitae 202
Publications 203
Dankwoord (Acknowledgments) 207
