Complex regional pain syndrome related movement disorders : studies on pathophysiology and therapy.
Munts, A.G.
Citation
Munts, A. G. (2011, November 2). Complex regional pain syndrome related movement disorders : studies on pathophysiology and therapy. Retrieved from
https://hdl.handle.net/1887/18015
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Complex regional pain syndrome related movement disorders
Studies on pathophysiology and therapy
Alexander G. Munts
Alexander G. Munts
Complex regional pain syndrome related movement disorders: studies on pathophysiology and therapy
PhD thesis, Leiden University Medical Centre, Leiden 2011 ISBN: 978-90-5335-449-0
©2011 Alexander Munts
Copyright of the individual chapters lies with the publisher of the journal listed at the beginning of each respective chapter.
Printed by: Ridderprint, Ridderkerk
Complex regional pain syndrome related movement disorders
Studies on pathophysiology and therapy
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 2 november 2011 klokke 16.15 uur
door
Alexander Gerard Munts geboren te Dordrecht
in 1973
Promotiecommissie
Promotor
Prof.dr. J.J. van Hilten
Co-promotor Dr. J. Marinus
Overige leden Prof.dr. R.A.C. Roos Prof.dr. A. Dahan
Dr. R.S.G.M. Perez (VU medisch centrum, Amsterdam)
These studies were performed within TREND (Trauma Related Neuronal Dysfunction), a knowledge consortium that integrates research on Complex Regional Pain Syndrome type 1. The project is supported by a Dutch Government grant (BSIK03016).
Financial support for the publication of this thesis has been provided by Abbott Products, Astellas Pharma, Boehringer Ingelheim, GlaxoSmithKline, Ipsen Farmaceutica, MSD, Sanofi-aventis, Shire Human Genetic Therapies and Teva.
For my parents
Contents
Chapter 1. General introduction and aims ... 9
Chapter 2. How psychogenic is dystonia? Views from past to present (Brain 2010;133:1552-64) ... 19
Chapter 3. Thermal hypesthesia in patients with complex regional pain syndrome related dystonia (J Neural Transm 2011;118:599-603) ... 49
Chapter 4. Fixed dystonia in complex regional pain syndrome: a descriptive and computational modelling approach (BMC Neurol 2011;11:53, revised) ... 59
Chapter 5. Analysis of cerebrospinal fluid inflammatory mediators in chronic complex regional pain syndrome related dystonia (Clin J Pain 2008;24:30-4) ... 77
Chapter 6. Clinical and neurophysiological characterisation of myoclonus in complex regional pain syndrome (Mov Disord 2008;23:581-7) ... 89
Chapter 7. Intrathecal baclofen for dystonia of complex regional pain syndrome (Pain 2009;143:41-7) ... 105
Chapter 8. Intrathecal glycine for pain and dystonia in complex regional pain syndrome (Pain 2009;146:199-204) ... 125
Chapter 9. Efficacy and safety of a single intrathecal methylprednisolone bolus in chronic complex regional pain syndrome (Eur J Pain 2010;14:523-8) ... 141
Chapter 10. Post-dural puncture headache in complex regional pain syndrome: a retrospective observational study (Pain Med 2009;10:1469-75) ... 155
Chapter 11. Summary and conclusions ... 167
Chapter 12. Samenvatting en conclusies (Dutch) ... 177
List of publications ... 187
Curriculum Vitae ... 189
Acknowledgements/Dankwoord ... 191