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Complex regional pain syndrome related movement disorders : studies on pathophysiology and therapy.

Munts, A.G.

Citation

Munts, A. G. (2011, November 2). Complex regional pain syndrome related movement disorders : studies on pathophysiology and therapy. Retrieved from

https://hdl.handle.net/1887/18015

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/18015

Note: To cite this publication please use the final published version (if applicable).

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Complex regional pain syndrome related movement disorders

Studies on pathophysiology and therapy

Alexander G. Munts

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Alexander G. Munts

Complex regional pain syndrome related movement disorders: studies on pathophysiology and therapy

PhD thesis, Leiden University Medical Centre, Leiden 2011 ISBN: 978-90-5335-449-0

©2011 Alexander Munts

Copyright of the individual chapters lies with the publisher of the journal listed at the beginning of each respective chapter.

Printed by: Ridderprint, Ridderkerk

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Complex regional pain syndrome related movement disorders

Studies on pathophysiology and therapy

Proefschrift ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van de Rector Magnificus Prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties

te verdedigen op woensdag 2 november 2011 klokke 16.15 uur

door

Alexander Gerard Munts geboren te Dordrecht

in 1973

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Promotiecommissie

Promotor

Prof.dr. J.J. van Hilten

Co-promotor Dr. J. Marinus

Overige leden Prof.dr. R.A.C. Roos Prof.dr. A. Dahan

Dr. R.S.G.M. Perez (VU medisch centrum, Amsterdam)

These studies were performed within TREND (Trauma Related Neuronal Dysfunction), a knowledge consortium that integrates research on Complex Regional Pain Syndrome type 1. The project is supported by a Dutch Government grant (BSIK03016).

Financial support for the publication of this thesis has been provided by Abbott Products, Astellas Pharma, Boehringer Ingelheim, GlaxoSmithKline, Ipsen Farmaceutica, MSD, Sanofi-aventis, Shire Human Genetic Therapies and Teva.

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For my parents

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Contents

Chapter 1. General introduction and aims ... 9

Chapter 2. How psychogenic is dystonia? Views from past to present (Brain 2010;133:1552-64) ... 19

Chapter 3. Thermal hypesthesia in patients with complex regional pain syndrome related dystonia (J Neural Transm 2011;118:599-603) ... 49

Chapter 4. Fixed dystonia in complex regional pain syndrome: a descriptive and computational modelling approach (BMC Neurol 2011;11:53, revised) ... 59

Chapter 5. Analysis of cerebrospinal fluid inflammatory mediators in chronic complex regional pain syndrome related dystonia (Clin J Pain 2008;24:30-4) ... 77

Chapter 6. Clinical and neurophysiological characterisation of myoclonus in complex regional pain syndrome (Mov Disord 2008;23:581-7) ... 89

Chapter 7. Intrathecal baclofen for dystonia of complex regional pain syndrome (Pain 2009;143:41-7) ... 105

Chapter 8. Intrathecal glycine for pain and dystonia in complex regional pain syndrome (Pain 2009;146:199-204) ... 125

Chapter 9. Efficacy and safety of a single intrathecal methylprednisolone bolus in chronic complex regional pain syndrome (Eur J Pain 2010;14:523-8) ... 141

Chapter 10. Post-dural puncture headache in complex regional pain syndrome: a retrospective observational study (Pain Med 2009;10:1469-75) ... 155

Chapter 11. Summary and conclusions ... 167

Chapter 12. Samenvatting en conclusies (Dutch) ... 177

List of publications ... 187

Curriculum Vitae ... 189

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Acknowledgements/Dankwoord ... 191

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