Cardiovascular computed tomography for diagnosis and risk stratification of coronary artery disease
Werkhoven, J.M. van
Citation
Werkhoven, J. M. van. (2011, June 23). Cardiovascular computed tomography for diagnosis and risk stratification of coronary artery disease. Retrieved from https://hdl.handle.net/1887/17733
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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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J.M. van Werkhoven
Car dio vascular Comput ed Tomogr aph y f or Diagnosis and Risk Str atification of Cor onary Ar tery Disease J.M. v an W erkho ven
Computed Tomography
for Diagnosis and Risk Stratification
of Coronary Artery Disease
Cardiovascular
J.M. van Werkhoven
Car dio vascular Comput ed Tomogr aph y f or Diagnosis and Risk Str atification of Cor onary Ar tery Disease J.M. v an W erkho ven
Computed Tomography
for Diagnosis and Risk Stratification
of Coronary Artery Disease
Cardiovascular
Cardiovascular Computed Tomography for Diagnosis and Risk Stratification
of Coronary Artery Disease
J.M. van Werkhoven
The research described in this thesis was performed at the departments of Cardiology and Radiology of the Leiden University Medical Center, Leiden, the Netherlands.
Design: Judith A. van Werkhoven
Lay-out:: Optima Grafische Communicatie, Rotterdam, The Netherlands Printed by: Optima Grafische Communicatie, Rotterdam, The Netherlands ISBN: 978-94-6169-078-4
Copyright © 2011 J.M. van Werkhoven, The Hague, The Netherlands. All rights reserved. No parts of this book may be reproduced or transmitted, in any form or by any means, without prior permission by the author.
Financial support for the costs associated with the publication of this thesis was gratefully received from: Astellas Pharma BV, AstraZeneka BV, B.Braun Medical BV, Boehringer Ingel- heim BV, Boston Scientific Benelux BV, Bracco Imaging Europe BV, Meda Pharma BV, Merck Sharp & Dohm BV, Philips Healthcare, Sanofi-Aventis BV, Servier Nederland Pharma BV, St Jude Medical BV, Stichting Imago, and Toshiba Medical Systems BV.
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Cardiovascular Computed Tomography for Diagnosis and Risk Stratification
of Coronary Artery Disease
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 23 juni 2011
klokke 16:15 uur door
Jacob Marinus van Werkhoven geboren te ’s Gravenhage
in 1983
Promotiecommissie
Promotores: Prof. dr. J.J. Bax Prof. dr. J.W. Jukema Prof. dr. A. de Roos
Overige leden: Prof. dr. P.J. de Feyter (Erasmus Universiteit, Rotterdam) Prof. dr. J.H.C. Reiber
Prof. dr. M.J. Schalij
dr. J.H.M. Schreur (MC Haaglanden, Den Haag) Prof. dr. E.E. Van der Wall
The research described in this thesis was supported by a grant from the Netherlands Society of Cardiology and the Interuniversity Cardiology Institute of the Netherlands.
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“l’existence précède l’essence”
(Jean-Paul Sartre)
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Table of Contents
Chapter 1: General introduction and outline 10
Part 1 Cardiovascular Computed Tomography for diagnosis of coronary artery disease
Chapter 2: Multi-slice computed tomography coronary angiography:
anatomic vs functional assessment in clinical practice Minerva Cardioangiol 2008
20
Chapter 3: Diagnostic accuracy of computed tomography coronary angiography in patients with an intermediate pre-test likeli- hood for coronary artery disease
Am J Cardiol 2010
38
Chapter 4: Invasive versus noninvasive evaluation of coronary artery disease
J Am Coll Cardiol Img 2008
50
Chapter 5: Anatomic correlates of a normal perfusion scan using 64-slice computed tomographic coronary angiography Am J Cardiol 2008
68
Chapter 6: Comparison of Non-Invasive Multi-Slice Computed Tomog- raphy Coronary Angiography versus Invasive Coronary Angiography and Fractional Flow Reserve for the Evaluation of Men with Known Coronary Artery Disease
Am J Cardiol 2009
82
Chapter 7: Combined non-Invasive anatomic and functional assess- ment with MSCT and MRI for the detection of significant coronary artery disease in patients with an intermediate pre-test likelihood
Heart 2010
94
Chapter 8: Predictive value of multislice computed tomography vari- ables of atherosclerosis for ischemia on stress-rest single- photon emission computed tomography
Circ Cardiovasc Imaging 2010
112
Chapter 9: Impact of clinical presentation and pre-test likelihood on the relation between coronary calcium score and computed tomography coronary angiography
Am J Cardiol 2010
132
Part 2 Cardiovascular computed tomography for risk stratification of coronary artery disease
Chapter 10: The value of multi-slice computed tomography coronary angiography for risk stratification
J Nucl Cardiol 2009
146
Chapter 11: Prognostic value of multislice computed tomography and gated single-photon emission computed tomography in patients with suspected coronary artery disease
J Am Coll Cardiol 2009
168
Chapter 12: Incremental prognostic value of multi-slice computed tomography coronary angiography over coronary artery calcium scoring in patients with suspected coronary artery disease
Eur Heart J 2009
186
Chapter 13: Incremental prognostic value of left ventricular function analysis over non-invasive coronary angiography with multi- detector computed tomography
J Nucl Cardiol 2010
204
Chapter 14: Multi-slice computed tomography coronary angiography for risk stratification in patients with an intermediate pre-test likelihood.
Heart 2009
218
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Chapter 15: Diabetes: prognostic value of computed tomography coro- nary angiography--comparison with a nondiabetic popula- tion
Radiology 2010
232
Chapter 16: Influence of smoking on the prognostic value of cardiovas- cular computed tomography coronary angiography
Eur Heart J 2011
252
Part 3 Future perspectives
Chapter 17: Myocardial perfusion imaging to assess ischemia using mul- tislice computed tomography
Expert Rev Cardiovasc Ther 2009
268
Chapter 18: Diastolic heart function assessed with MDCT: feasibility study in comparison with tissue doppler
J Am Coll Cardiol Img 2011
282
Summary and Conclusions 303
Samenvattingen en Conclusies 311
List of Publications 321
Dankwoord 331
Curriculum Vitae 335
