Transanal endoscopic microsurgery in rectal cancer
Doornebosch, P.G.
Citation
Doornebosch, P. G. (2010, June 10). Transanal endoscopic microsurgery in rectal cancer. Retrieved from https://hdl.handle.net/1887/15683
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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CHAPTER 2
Aim of the thesis
Aim of the thesis 27
AIM OF THE THESIS
Local excision, and in particular transanal endoscopic microsurgery (TEM), is increasingly being applied in the treatment of T1 rectal cancer. In several national guidelines this treatment option is incorporated, however several issues have to be addressed before this is justified.
Chapter 1 contains a review of the relevant literature on TEM for T1 rectal cancer.
The aim of the thesis, outlined here in chapter 2, is to define which T1 rectal cancers are suit- able for TEM, in order to improve outcome. Besides oncologic outcome, quality of life (QOL) after TEM is studied and compared to after TME. Also, possible improvements regarding tumor selection are explored.
In chapter 3 oncologic outcome after TEM for T1 rectal cancer is studied and directly compared to after TME.
Chapter 4 studies the possible salvage options and outcome in recurrent tumors following TEM for T1 rectal cancer.
Chapter 5 is a study on QOL following TEM and in chapter 6 QOL after TEM is compared to QOL after TME.
In chapter 7 we investigated whether endorectal ultrasound could identify tumors possibly suitable for TEM.
In chapter 8 we performed a study upon tumor analysis in order to identify features suggestive of rectal cancer in (presumed) rectal adenomas.
Chapter 9 contains an analysis of histopathological features, which may be predictive for a local recurrence in T1 rectal cancer, treated solely with TEM.
Chapter 10 contains a summary, which is also given in Dutch in chapter 11.
