Cover Page
The handle http://hdl.handle.net/1887/3161375 holds various files of this Leiden
University dissertation.
Author: Zhou, E.
Title: Novel pathways in cholesterol metabolism to combat cardiometabolic diseases
Issue date: 2021-04-28
Novel pathways in cholesterol metabolism
to combat cardiometabolic diseases
Copyright © Enchen Zhou, 2021
All right reserved. No part of this thesis may be transformed, reproduced or transmitted in any form by any means without prior permission of the author.
Novel pathways in cholesterol metabolism
to combat cardiometabolic diseases
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden,
op gezag van rector magnificus Prof.dr.ir. H. Bijl,
volgens besluit van het college voor promoties
te verdedigen op woensdag 28 april 2021
klokke 10:00 uur
door
Enchen Zhou
geboren te Gongzhuling, China
in 1991
PROMOTIECOMMISSIE
Prof. dr. J.A.P. Willems van Dijk
Prof. dr. M.P.J. de Winther (AUMC, Amsterdam) Prof. dr. R. Shiri-Sverdlov (MUMC, Maastricht)
The work described in this thesis was performed at the Department of Medicine, Division of Endocrinology of the Leiden University Medical Center, Leiden, the Netherlands.
Table of contents
Chapter 1 General introduction and outline 1
Chapter 2 Beneficial effects of brown fat activation on top of PCSK9 inhibition with alirocumab on dyslipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice
23
Chapter 3 Hepatic SRB1 knockdown reduces atherosclerosis and enhances the anti-atherosclerotic effect of brown fat activation in APOE*3-Leiden.CETP mice
47
Chapter 4 Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development
79
Chapter 5 Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution
109
Chapter 6 Inhibition of Δ24-dehydrocholesterol reductase ameliorates diet-induced hepatic steatosis and inflammation through LXRα without inducing hyperlipidemia
149
Chapter 7 FXR activation resolves dyslipidemia and decreases adiposity in APOE*3-Leiden.CETP-transgenic mice fed a Western-type diet
177
Chapter 8 General discussion and future perspectives 199
Chapter 9 Summary 213
Samenvatting 219
List of publications 223
Curriculum Vitae 225
