Celiac disease : from basic insight to therapy development
Stepniak, D.T.
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Stepniak, D. T. (2006, December 14). Celiac disease : from basic insight to
therapy development. Retrieved from https://hdl.handle.net/1887/5435
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Celiac Disease
Celiac Disease
From Basic Insight to Therapy Development
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Dr.D.D.Breimer,
hoogleraar in de faculteit der Wiskunde en
Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 14 december 2006
klokke 15:00 uur
door
Dariusz Tomasz Stępniak
PROMOTIECOMMISSIE:
Promotor: Prof. Dr. F. KoningReferent: Prof. Dr. C. J. J. Mulder (VUMC) Overige leden: Prof. Dr. F. H. J. Claas
Prof. Dr. D. W. Hommes Prof. Dr. E. J. H. J. Wiertz
The research described in this thesis was conducted at the Department of Immunohematology and Blood Transfusion of the Leiden University Medical Center.
This project was supported by the Netherlands Organization for Scientific Research (grant 912-02-028) and the Celiac Disease Consortium, an innovative cluster approved by the Netherlands Genomics Initiative and partially funded by the Dutch Government (BSIK03009). © D. T. Stepniak, 2006. All rights reserverd.
ISBN-10: 90-9021209-4 ISBN-13: 978-90-9021209-8
Layout and cover design: D.T. Stepniak Printed by: Offsetdrukkerij Nautilus, Leiden
They do certainly give very strange and newfangled names to diseases.
C
ONTENTS13 Chapter 1 General introduction: Celiac disease - sandwiched
between innate and adaptive immunity. Hum Immunol. 2006 Jun; 67(6): 460-8. Chapter 2 Large-scale characterization of natural ligands
explains the unique gluten-binding properties of HLA-DQ2. (submitted)
33
59 Chapter 3 T-cell recognition of HLA-DQ2-bound gluten
peptides can be influenced by an N-terminal proline at p-1. Immunogenetics. 2005 Apr; 57 (1-2): 8-15.
77 Chapter 4 Characterization of cereal toxicity for celiac disease
patients based on protein homology in grains.
Gastroenterology. 2003 Oct; 125(4): 1105-13.
97 Chapter 5 No genetic association of the human prolyl
endo-peptidase gene in the Dutch celiac disease population. Am J Physiol Gastrointest Liver
Physiol. 2005 Sep; 289(3): G495-500.
115 Chapter 6 Highly efficient gluten degradation with a newly
identified prolyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver
