Fetal fluid and protein dynamics
Pasman, S.
Citation
Pasman, S. (2010, January 21). Fetal fluid and protein dynamics. Retrieved from https://hdl.handle.net/1887/14601
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Fetal fluid and protein dynamics
S.A. Pasman
Financial support by Stichting Intrauteriene Diagnostiek en Behandeling,
BMA BV (Mosos), Sorg-Saem BV (Astraia) and Stichting Sanquin Bloedvoorziening for the publication of this thesis is gratefully acknowledged.
Cover design: S.J. Peters and L.J. Wisse (sculpture by S.A. Pasman) Lay-out: Wendy Schoneveld
Printed by: Gildeprint drukkerijen - Enschede
ISBN/EAN: 978-94-901-2292-8
© 2010 S.A. Pasman, Leiden, The Netherlands
Fetal fluid and protein dynamics
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens het besluit van het College voor Promoties
te verdedigen op donderdag 21 januari 2010 klokke 16.15 uur
door
Suzanne Pasman
geboren te Nieuwegein in 1977
Promotiecommissie:
Promotor: Prof. Dr. H.H.H. Kanhai
Co-promotores: Dr. F.P.H.A. Vandenbussche Dr. D. Oepkes
Overige leden: Prof. Dr. A. Brand Dr. E. Mulder
Universitair Medisch Centrum Utrecht Prof. Dr. J.G. Nijhuis
Maastricht Universitair Medisch Centrum Prof. Dr. F.J. Walther
Aan elke foetus die ooit foetale therapie nodig zal hebben
Voor iedereen die mij dierbaar is en ooit een foetus was
Contents
chapter 1: General introduction 9
introduction 11 background 13
outline of the thesis 16
chapter 2: On the origin of amniotic fluid bilirubin 19 (Placenta 2004; 25(5): 463-468)
chapter 3: Bilirubin/albumin ratios in fetal blood and in
amniotic fluid in Rh-immunization 33
(Obstet Gynecol 2008; 111(5): 1083-1088)
chapter 4: Origin and function of amniotic fluid albumin:
a review of the available evidence 49
(Submitted for publication)
chapter 5: Hypoalbuminemia: a cause of fetal hydrops? 75 (Am J Obstet Gynecol 2006; 194(4): 972-975)
chapter 6: Total blood volume is maintained in nonhydropic fetuses
with severe hemolytic anemia. 87
(Fetal Diagn Ther 2009; 26(1):10-5)
chapter 7: Fluid shift out of the fetal circulation during intrauterine
red cell transfusion 101
(Submitted for publication)
chapter 8: General discussion 115
insights in fetal (patho-)physiology 116 implications for current practice 120 implications for future research 126
chapter 9: Summary 133
Nederlandse samenvatting 138
List of abbreviations 143
Authors and affiliations 145
Publications 146
Curriculum vitae 149
Dankwoord 151
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