Huntington’s disease : hypothalamic, endocrine and metabolic aspects Aziz, N.A.

To evaluate whether hypocretin-1 (orexin-A) and melanin-concentrating hormone (MCH) neurotransmission are affected in patients with Huntington’s disease (HD), we

The large supply of blood which they receive from three separate sources; their numerous nerves, derived immediately from the semilunar ganglia and solar plexus; their early

Our hypothesis of diminished hypothalamic feedback as the primary cause of elevated plasma cortisol levels in HD patients would imply either decreased regularity (i.e. increased

39 These ghrelin secretion pathways seem to be relatively spared in early stages of HD as fasting ghrelin levels as well as postprandial suppression of ghrelin release

Although daily TSH production rates were similar between HD patients and matched controls, thyroid hormone levels were significantly higher in HD patients, consistent with a

Thus, in order to assess adipose tissue function and its relation to body weight in HD patients, we assessed 24 h plasma leptin, adiponectin and resistin concentration profiles

In order to test these hypotheses, we (1) compared 24 h plasma melatonin concentration profiles between early stage, medication-free HD patients and healthy

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Downloaded