Microscopical evaluation of prognostic factors in colorectal cancer
Mesker, W.E.
Citation
Mesker, W. E. (2008, June 12). Microscopical evaluation of prognostic factors in colorectal cancer. Retrieved from https://hdl.handle.net/1887/12950
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12950
Note: To cite this publication please use the final published version (if
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Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 12 juni 2008
klokke 16.15 uur
door
Wilhelmina Engelina Mesker
geboren te Leiden in 1963
Microscopical evaluation of prognostic factors
in colorectal cancer
Promotiecommissie
Promotores: Prof. Dr. H.J. Tanke
Prof. Dr. R.A.E.M. Tollenaar Co-promotor: Dr. K. Szuhai
Referent: Prof. Dr. J.H.J.M. van Krieken, UMC St Radboud, Nijmegen Overige leden: Prof. Dr. C.J.H. van de Velde
Cover: Nick en Isabelle Heemskerk, 2008
Printed by Pasmans Offsetdrukkerij BV, Den Haag
The work presented in this thesis was supported in part by the European Community’s Sixth Framework program (DISMAL project, LSHC-CT-2005- 018911), Applied Imaging a Genetix Company, Zon-MW 945-05-021, the “Anna en Maurits de Kock Foundation”, the Dutch Cancer Society (Grant 2000-2211) and the European Community’s Sixth Framework program (Tumor-Host Genomics-1276640).
Financial support for publication of this thesis was kindly provided by:
Leica Microsystems B.V, Covidien Nederland B.V., Merck Serono.
With special thanks for their generous support to Applied Imaging a Genetix Company.
I have sent you my invitation,
the note inscribed on the palm of my hand by the fire of living.
Don't jump up and shout, "Yes, this is what I want! Let's do it!"
Just stand up quietly and dance with me.
- Oriah Mountain Dreamer, The Dance -
Lieve Pa, voor jou
Table of contents
Chapter 1 General Introduction 7
Chapter 2 Detection of tumor cells in bone marrow, peripheral blood and lymph 23 nodes by automated imaging devices.
Cell Oncol 2006; 28(4):141-150.
Chapter 3 Automated analysis of multiple sections for the detection of occult 35 cells in lymph nodes
Clin Cancer Res 2003; 9(13):4826-4834.
Chapter 4 Differences in genomic profiles of colorectal tumors of patients with 47 and without disseminated tumor cells in the bone marrow.
Chapter 5 The carcinoma–stromal ratio of colon carcinoma is an independent 65 factor for survival compared to lymph node status and tumor stage.
Cell Oncol. 2007; 29(5):387-98.
Chapter 6 Presence of a high amount of stroma and downregulation of SMAD4 79 predict for worse survival for stage I-II colon cancer patients.
Submitted.
Chapter 7 Summary and General Discussion 95
Chapter 8 Nederlandse samenvatting 107
Curriculum Vitae 115
List of publications 117
Figures chapters 3, 4 and 6 (color) 121
