Customized aortic repair : an alternative approach to aortic aneurysm repair using injectable elastomer
Bosman, W.M.P.F.
Citation
Bosman, W. M. P. F. (2011, September 1). Customized aortic repair : an alternative approach to aortic aneurysm repair using injectable elastomer.
Retrieved from https://hdl.handle.net/1887/17803
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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Customized Aortic Repair:
an alternative approach to aortic aneurysm repair using injectable elastomer
Willem-Maarten PF Bosman
Promotiecommissie
Promotor: Prof. Dr. J.F. Hamming (Universiteit Leiden)
co-promotor: Dr. A.C. de Vries (Medisch Centrum Haaglanden)
overige leden: Prof. Dr. M.J. Jacobs (Universiteit Maastricht) Prof. Dr. J.H. van Bockel (Universiteit Leiden) Dr. C.S.P. van Rijswijk (Universiteit Leiden)
oppositie commissie: Prof. Dr. F.L. Moll (Universiteit Utrecht) Dr. H.L.F. Brom (Kennemer Gasthuis)
Dr. C.H.R. Bosman (Medisch Centrum Haaglanden) Dr. J.W. Hinnen (Universiteit Leiden)
Paranimfen: Dr. K.E.A. van der Bogt (Universiteit Leiden) Drs. R.D. Vriesendorp (Universiteit Leiden)
ISBN: 978-94-6169-106-4
Layout and printing: Optima Grafische Communicatie, Rotterdam, The Netherlands
This thesis, including additional multimedia material, is also available as webapp on:
www.customizedaorticrepair.com
Scan the QR-code with your smartphone or tablet and it will take you to the website for the webapp.
customized Aortic repair:
an alternative approach to aortic aneurysm repair using injectable elastomer
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 1 september 2011 klokke 15:00 uur
door
Willem-maarten Pieter Frederik Bosman
geboren te ‘s Gravenhage in 1981
Research described in this thesis was performed at the Department of Surgery of the Leiden University Medical Center.
Financial support for this thesis was provided by:
Leiden University Fund - Gratama Foundation Ketel 1 Studiefonds
LUMC Heelkunde Fonds Rijnland Ziekenhuis
Research Fonds Rijnland Ziekenhuis CAR B.V. i.o.
Vascutek Nederland - a Terumo company W.L. Gore & Associates
TD Medical B.V.
Sigma Medical AngioCare B.V.
B. Braun Medical B.V.
Oldelft Benelux B.V.
ChipSoft B.V.
Sanofi-BMS
Astellas Pharma B.V.
Krijnen Medical Innovations B.V.
Bard Benelux N.V.
Heart Medical B.V.
Oudshoorn Chirurgische Techniek B.V.
the printing of this thesis was financially supported by:
The J.E. Jurriaanse Stichting The Netherlands Heart Foundation
“If you only have a hammer, every problem looks like a nail”
- Abraham Manslow
Voor mijn familie
tABle oF contents
chapter 1 General introduction 9
chapter 2 The effect of stent-graft compliance on
endotension after EVAR. 27
chapter 3 Influence of aneurysm wall stiffness and the presence of intraluminal thrombus on the wall movement of an aneurysm. An in-vitro study.
43
chapter 4 Aortic Customize: a new alternative endovascular approach to Aortic Aneurysm repair using injectable biocompatible elastomer. An in-vitro study.
57
chapter 5 The proximal fixation strength of modern EVAR-
grafts in a short aneurysm neck. An in-vitro study. 75 chapter 6 The effect of injectable biocompatible elastomer
(PDMS) on the strength of the proximal fixation of EVAR-grafts. An in-vitro study.
91
chapter 7 Treating type II-IV endoleaks by injecting biocom- patible elastomer (polydimethylsiloxane; PDMS) in the aneurysm sac. An in-vitro study.
107
chapter 8 Thrombogenicity of a new injectable biocompatible elastomer for aneurysm exclusion, compared to expanded polytetrafluoroethylene in a human ex-vivo model.
123
chapter 9 Aortic customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using injectable elastomer.
137
chapter 10 Summary and discussion. 151
chapter 11 Samenvatting in het Nederlands 167
chapter 12 Addenda: 177
Abbreviations 179
List of Publications 181
Curriculum Vitae 185
Acknowledgements 187
Colofon 190
