Improving breast cancer outcome by preoperative systemic therapy and image-guided surgery
Mieog, J.S.D.
Citation
Mieog, J. S. D. (2011, October 26). Improving breast cancer outcome by preoperative systemic therapy and image-guided surgery. Retrieved from https://hdl.handle.net/1887/17983
Version: Corrected Publisher’s Version License:
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University of Leiden
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Improving breast cancer outcome by preoperative systemic therapy and image-guided surgery
Sven Mieog
Printed by Optima Grafische Communicatie, Rotterdam Cover design by Caro van Dijk
ISBN 978-94-6169-150-7
© J.S.D. Mieog, 2011, Leiden, the Netherlands. All rights reserved. No parts of this publication may be reproduced or transmitted in any form or by any means, without prior written permission of the author.
Thesis Mieog.indb 2 22-09-11 19:49
Improving breast cancer outcome by preoperative systemic therapy and image-guided surgery
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. mr. P.F. van der Heijden, volgens besluit van het college voor Promoties
te verdedigen op woensdag 26 oktober 2011 klokke 16.15 uur
door
Jan Sven David Mieog geboren te Monster
in 1980
Promotiecommissie
Promotor Prof. dr. C.J.H. van de Velde Co-promotor Dr. A.L. Vahrmeijer
Overige leden Prof. dr. C.W.G.M. Löwik Prof. dr. J.W.R. Nortier
Prof. dr. M.J. van de Vijver (Universiteit van Amsterdam) Dr. P.J.K. Kuppen
Dr. G.J. Liefers Dr. V.T.H.B.M. Smit
The author of this thesis is a MD-medical research trainee funded by the The Netherlands Organisation for Health Research and Development (grant nr. 92003526). The research described in this thesis was financially supported by the Center for Translational Molecular Medicine (CTMM, DeCoDe and MUSIS projects), the Dutch Cancer Society (KWF 2007-3968 and UL 2010-4732), and the Sacha Swarttouw-Hijmans Foundation.
Financial support by J.E. Jurriaanse Foundation, Pfizer, Novartis, Roche, Sanofi-Aventis, GSK, ChipSoft, Caliper Life Sciences, LI-COR Biosciences, PerkinElmer and Percuros for the publication of this thesis is gratefully acknowledged.
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Voor mijn ouders Aan Anne
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Contents
Chapter 1 General introduction and outline of thesis 9
Part I Preoperative systemic therapy
Part IA Preoperative therapy and personalized treatment
Chapter 2 Neoadjuvant chemotherapy for operable breast cancer: a Cochrane
systematic review 23
Chapter 3 Tumor response to preoperative anthracycline-based chemotherapy in operable breast cancer: the predictive role of p53 expression 39 Chapter 4 Efficacy of adjuvant chemotherapy according to hormone receptor
status in young patients with breast cancer: a pooled analysis 55 Chapter 5 Impact of established prognostic factors and molecular subtype in
very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials
69
Part IB Resistance to therapy and cancer stem cells
Chapter 6 Age interactions in the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer 87 Chapter 7 Alternatively spliced and full-length tissue factor reveal a non-
identical relationship to clinicopathological parameters in a large cohort of human breast cancer
101
Part II Image-guided surgery
Part IIA Intraoperative tumor detection
Chapter 8 Novel intraoperative near-infrared fluorescence camera system for
optical image-guided cancer surgery 121
Chapter 9 Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer 137 Chapter 10 Antibody-based intraoperative near-infrared fluorescence imaging
of primary breast cancer in a syngeneic rat model 157
Part IIB sentinel lymph node mapping
Chapter 11 Towards optimization of imaging system and lymphatic tracer for near-infrared fluorescent sentinel lymph node mapping in breast cancer
175
Chapter 12 Randomized, double-blind comparison of indocyanine green with or without albumin premixing for near-infrared fluorescence imaging of sentinel lymph nodes in breast cancer patients
191
Chapter 13 Summary and general discussion 205
Chapter 14 Nederlandse samenvatting 217
List of publications 223
Curriculum Vitae 227
Dankwoord 229
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