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Anthracycline-induced cardiotoxicity, a pathophysiology based approach for early detection and protective strategies

Broeyer, F.J.F.

Citation

Broeyer, F. J. F. (2012, January 17). Anthracycline-induced cardiotoxicity, a pathophysiology based approach for early detection and protective strategies. Retrieved from https://hdl.handle.net/1887/18360

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded

from: https://hdl.handle.net/1887/18360

Note: To cite this publication please use the final published version (if applicable).

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anthracycline-induced cardiotoxicity, a pathophysiology

based approach for early detection and protective strategies

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anthracycline-induced cardiotoxicity a pathophysiology based approach for early

detection and protective strategies

proefschrift

ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr.P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op dinsdag 17 januari 2012 klokke 11.15

door

Frederik Jan Ferdinand Broeyer, geboren te Utrecht in 1979

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inhoudsopgave

chapter 1

8 Introduction and outline of the thesis

chapter 2

30 Evaluation of biomarkers for cardiotoxicity of anthracycline-based chemotherapy

chapter 3

48 Disturbed iron metabolism due to anthracycline-based

chemotherapy in early stage, surgically cured female breast cancer patients

chapter 4

64 Increased Beat-to-Beat variation of the qt-interval in early-stage breast cancer patients treated with doxorubicin

chapter 5

78 The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (pc-sod) in man

chapter 6

96 The pharmacokinetics of pc-sod, a lecithinized recombinant superoxide dismutase, after single- and multiple-dose administration to healthy Japanese and Caucasian volunteers.

chapter 7

114 Evaluation of lecithinized human recombinant super oxide dismutase as cardioprotectant in anthracycline-treated breast cancer patients

chapter 8

138 Summary and discussion 150 Nederlandse Samenvatting 155 Dankwoord

159 Lijst van publicaties promotiecommissie

promotores

Prof. Dr. A.F. Cohen, promotor Prof. Dr. S. Osanto, promotor Dr. J. Burggraaf, co-promotor

beoordelingscommissie Prof. Dr. P.A.F.M. Doevendans Prof. Dr. H.J. Guchelaar Prof. Dr. D.J. Richel

design

Caroline de Lint, Voorburg (caro@delint.nl)

acknowledgements

The publication of this thesis was financially supported

by the foundation Centre for Human Drug Research (chdr),

Leiden, the Netherlands

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