Cover Page The handle http://hdl.handle.net/1887/44789

midazolam in obese adolescents (Chapter 4) and morbidly obese adults (Chapter 7) to evaluate the difference in midazolam clearance and explore a model that can be used to

For propofol, researchers performed a population pharmacokinetic meta-analysis with data from morbidly obese adults, adolescents, and children and their nonobese controls (body

Title: The impact of obesity on the pharmacokinetics of drugs in adolescents and adults Issue Date: 2016-12-07..

total body weight (TBW) in 19 overweight and obese adolescents of the base pharmacokinetic model with increase between peripheral volume of distribution with TBW according to

However, as this difference in age is small, this study suggests in our opinion that the increase in oral clearance (CL/F) of metformin in obese adolescents may be explained by

Hence, the final model selected to describe 24-hour variation in midazolam con- centration profiles included a cosine function for bioavailability and clearance and a

The results from this study show that midazolam clearance was similar in morbidly obese patients and healthy volunteers, oral bioavailability was substantially higher (60% instead

The aim of this study was to determine the pharmacokinetics of acetaminophen with a specific emphasis on the contributions of the metabolites (glucuronide, sulphate,