University of Groningen
Predicting asthma phenotypes: characterization of IL1RL1 in asthma
Dijk, Fokelina Nicole
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Publication date: 2018
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Dijk, F. N. (2018). Predicting asthma phenotypes: characterization of IL1RL1 in asthma. Rijksuniversiteit Groningen.
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Predicting asthma phenotypes:
characterization of IL1RL1 in asthma
Paranimfen
I. Marlies Barre-Wabeke Marie E. Ketelaar
-The research described in this thesis was performed at the Department of Pediatric Pul-monology and Pediatric Allergology, Beatrix Children’s Hospital, University Medical Centre Groningen, Groningen, The Netherlands.
The studies presented in this thesis were funded by the Lung Foundation of the Nether-lands (grant no. AF 95.05, AF 98.48, AF3.2.09.081JU and AF 3.4.05.033), the Stichting Ast-ma Bestrijding (SAB 2006/018), the MeDALL study (European Union, FP7 project, grant agreement No. 261357) and the Ubbo Emmius Fund.
Publication of this thesis was financially supported by the University Medical Centre Groningen, the University of Groningen, and the Graduate School GUIDE of the University of Groningen. The author gratefully acknowledge the financial support for printing of this thesis by Stichting Astma Bestrijding (SAB) and the Lung Foundation of the Netherlands. Cover design and lay out by Ellen Beck
Printed by Gildeprint
ISBN 978-94-034-1132-3 (printed version) ISBN 978-94-034-1131-6 (digital version) Copyright© F.N. Dijk, 2018
Promotores
Prof. dr. G.H. Koppelman Prof. dr. D.S. Postma
Beoordelingscommissie
Prof. dr. H.M. Boezen Prof. dr. C.K. van der Ent Prof. dr. J.V. Fahy
Hoe wild de golven ook zijn,
vergeet nooit de vuurtoren waar je
naar op weg bent
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Chapter 1 General introduction (Page 8) Chapter 2Genetics of onset of asthma (Page 26)
Chapter 3
Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood (Page 40)
Chapter 4
Phenotypic and functional translation of IL1RL1 locus polymorphisms in lung tissue and airway epithelium in asthma
(Page 60) Chapter 5
Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma
Content
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Chapter 6
IL1RL1 gene variations are associated with
asthma exacerbations in children and adolescents using inhaled corticosteroids (Page 134)
Chapter 7
TRPA1 gene polymorphisms and
childhood asthma (Page 156) Chapter 8
Predictive value of serum sST2 in preschool wheezers for development of asthma with high FeNO
(Page 180)
Chapter 9
Genetic risk scores do not improve asthma prediction in childhood (Page 194)
Chapter 10
Summary, general discussion and implication of results
(Page 214) Chapter 11
• Nederlandse samenvatting • Dankwoord
• About the author • List of publications (Page 234)
