University of Groningen
Developments in the treatment of advanced melanoma
Sloot, Sarah
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Publication date: 2017
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Sloot, S. (2017). Developments in the treatment of advanced melanoma. University of Groningen.
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Dissertation propositions
1. Intralymphatic metastases are more prevalent after a sentinel node biopsy than after wide local excision alone (this dissertation)
2. The increase in intralymphatic metastasis after sentinel node biopsy in melanoma is caused by aggressive tumor behavior as opposed to entrapment of tumor cells due to interruption of lymph flow (this dissertation) 3. Treatment of metastatic melanoma has become more advanced with increased efficacy due to introducing new perfusion techniques, intralesional therapies and new systemic therapies (this dissertation) 4. For select locoregionally advanced patients, BRAF targeted therapy is a pro mising neoadjuvant strategy (this dissertation) 5. BRAF inhibitors don’t have direct carcinogenic effects, but rather potentiate preexisting initiating oncogenic events (this dissertation) 6. The prognosis of melanoma brain metastasis patients has vastly improved over the past decade which provides a better outlook for patients suffering from this disease (this dissertation) 7. Although the brain is still a common site for treatment failure in melanoma, the incidence of de novo brain metastasis does not differ based on treatment modality (this dissertation) 8. In the realm of ideas everything depends on enthusiasm… in the real world all rests on perseverance (Johann Wolfgang von Goethe) 9. Communication the human connection is the key to personal and career success (Paul J. Meyer)
10. The road to success is not easy to navigate, but with hard work, drive and passion, it’s possible to achieve the American dream (Tommy Hilfiger)
Sarah Sloot September, 2017
