University of Groningen
Advanced vascular imaging
de Boer, Stefanie Amarens
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2017
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de Boer, S. A. (2017). Advanced vascular imaging: Technical and clinical applications in type 2 diabetes.
Rijksuniversiteit Groningen.
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Advanced vascular imaging
Technical and clinical applications in type 2 diabetes
Financial support for this thesis was provided by University Medical Center Groningen, Jan Kornelis de Cock Stichting, Graduate School of Medical Sciences, Boehringer Ingelheim B.V. and Sanofi.
Finanial support for printing of this thesis was kindly provided by Bayer B.V., Boehringer Ingelheim B.V., DiagnOptics Technologies B.V., THS Tools and Sanofi.
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Advanced vascular imaging
Technical and clinical applications in type 2 diabetes ISBN: 978-94-034-0084-6 (electronic version)
ISBN: 978-94-034-0085-3 (printed book) Copyright © 2017 Stefanie Amarens de Boer
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without prior permission of the author, or when applicable, of the publishers of the scientific papers.
Cover: Julia de Jong
Layout and design by Legatron Electronic Publishing, Rotterdam Printed by Ipskamp Printing, Enschede
Advanced vascular imaging
Technical and clinical applications
in type 2 diabetes
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 27 september 2017 om 16.15 uur
door
Stefanie Amarens de Boer
geboren op 19 november 1987
PROMOTORES
Prof. dr. P.W. Kamphuisen Prof. dr. R.H.J.A. Slart
Prof. dr. H.J. Lambers Heerspink
COPROMOTOR
Dr. D.J. Mulder
BEOORDELINGSCOMMISSIE
Prof. dr. A.A. Voors Prof. dr. E.S. Stroes Prof. dr. M. Schäfers
PARANIMFEN
Drs. M. C. Hovinga – de Boer Drs. S.E. de Boer
Contents
Chapter 1 General introduction and aims of the thesis 9 Part I Technical applications
Chapter 2 Specialised imaging to identify high-risk plaque 27
Greenhalgh RM, ed. Vascular and endovascular challenges update. London: BIBA Publishing. BIBA Medical Ltd; 2016:5-12.
Chapter 3 18F-sodium fluoride positron emission tomography assessed micro- 39 calcifications in symptomatic and asymptomatic human carotid plaques
Submitted
Chapter 4 Performance evaluation of a semi-automated method for 57 18F-fluorodeoxyglucose uptake in abdominal visceral adipose tissue
Submitted
Part II Clinical applications in type 2 diabetes
Chapter 5 Arterial stiffness is positively associated with 18F-fluorodeoxyglucose 75 positron emission tomography-assessed subclinical vascular
inflammation in people with early type 2 diabetes
Diabetes Care. 2016;39:1440-1447.
Chapter 6 Effect of linagliptin on pulse wave velocity in early type 2 diabetes: 95
A randomized, double-blind, controlled 26-week trial (RELEASE)
Diabetes Obesity and Metabolism. 2017;19:1147-1154.
Chapter 7 Effect of linagliptin on arterial 18F-fluorodeoxyglucose positron emission 115 tomography uptake A randomized controlled trial (RELEASE)
Journal of the American College of Cardiology. 2017;69:1097-1098.
Chapter 8 Summary, general discussion and future perspectives 121
Chapter 9 Nederlandse samenvatting 139
Dankwoord 151
Curriculum Vitae 159
Bibliography 163
