University of Groningen
Breaking walls: combined peptidic activities against Gram-negative human pathogens
Li, Qian
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Publication date:
2019
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Li, Q. (2019). Breaking walls: combined peptidic activities against Gram-negative human pathogens.
University of Groningen.
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PROPOSITIONS
Associated with the PhD thesis
Breaking walls: combined peptidic activities against
Gram-negative human pathogens
Qian Li
1. The development of antibiotic resistance is a natural ecological
phenomenon, but the abuse and misuse of antibiotics is accel-erating the process.
2. Lantibiotic structures can be used as guidance for designing
novel non-lantibiotic and lantibiotic peptides (Rink et al., 2005;
Schmitt et al., 2019).
3. The protective outer-membrane of Gram-negative bacteria acts
as an efficient barrier to prevent the action of several antibiotics
(Jessica M. A. Blair, 2015).
4. Existing antibiotics against Gram-positive bacteria to which
resistance is abundant could have a second life against Gram-
negative pathogens when used in synergy with outer membrane
perturbing agents (this thesis)
5.
Production of modified peptides in good quantity and high ho-mogeneity remains challenging.
6.
It is possible to develop highly potent lantibiotic derivatives spe-cifically targeting Gram-negative bacteria, by rational design of
nisin (Chapter 3).
7.
Vancomycin/nisin and outer membrane disrupting peptides dis-play strong synergistic activity against selected Gram- negative
pathogens (Chapter 4 and Chapter 5).
8.
GNP-D8 is very promising to be registered as an adjuvant in clin-ical use against Gram-negative human pathogens (Chapter 5).
9. Three cobblers combined make a genius mind (三个臭皮匠，
顶个诸葛亮)(Chinese proverb).
10. When the going gets tough, the tough gets going.
