University of Groningen
Antenatal diagnosis and management of fetal megacystis and lower urinary tract obstruction
Fontanella, Federica
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Publication date: 2019
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Fontanella, F. (2019). Antenatal diagnosis and management of fetal megacystis and lower urinary tract obstruction. University of Groningen.
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Antenatal diagnosis and management of fetal megacystis
and lower urinary tract obstruction
Antenatal diagnosis and management of fetal megacystis and lower urinary tract obstruction
Federica Fontanella, The Netherlands, 2018 ISBN 978-94-034-1269-6
ISBN (PDF) 978-94-034-1268-9
Printed by Ridderprint BV, www.ridderprint.nl Layout by Jos Hendrix
Coverdesign and illustrations on page 17, 71, 101 by Laura Fontanella © 2018 F. Fontanella, Groningen, The Netherlands
The copyright of the articles that have been published has been transferred to the respective journals. No parts of this thesis may be reproduced or transmitted in any form by any means, without prior permission of the copyright owner.
Antenatal diagnosis and management
of fetal megacystis and lower urinary tract obstruction
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnifi cus prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 9 January 2019 at 14.30 hours
by
Federica Fontanella
born on 13 November 1989 in Rome, Italy
Supervisors Prof. C.M. Bilardo Prof. D. Oepkes Assessment Committee
Prof. A.F. Bos Prof. J.M. Nijman Prof. M.D. Kilby
Contents
Chapter 1 General introduction 7
Part 1 Fetal Megacystis: definition and differential diagnosis 17 Chapter 2 Reference charts of fetal urinary bladder in the second 19
and third trimester of pregnancy
Submitted
Chapter 3 Fetal megacystis: a lot more than LUTO 35
Ultrasound Obstet Gynecol 2018, in press
Chapter 4 Fetal Megacystis: Prediction of spontaneous resolution 57 and outcome
Ultrasound Obstet Gynecol 2017;50:458-63
Part 2 antenatal diagnosis and management of LUtO 71 Chapter 5 Antenatal work-up of early megacystis and selection 73
of candidates for fetal therapy
Fetal Diagn Ther, 2018
Chapter 6 Prenatal diagnosis of LUTO: improving diagnostic accuracy 87
Ultrasound Obstet Gynecol, 2017; in press
Part 3 Prediction of prognosis and staging of LUtO 101 Chapter 7 Antenatal staging of congenital Lower Urinary Tract 103
Obstructions (LUTO)
Ultrasound Obstet Gynecol 2018; in press
Chapter 8 Prediction model of postnatal renal function in fetuses with 117 LUTO – development and internal validation
Submitted
Chapter 9 Final discussion and future perspectives 131
Chapter 10 Summary in English 151
Nederlandse samenvatting 153
Abbreviations 155
Acknowledgements 157
About the author 161
