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Reverse cholesterol transport : a potential therapeutic target for atherosclerosis

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Reverse cholesterol transport : a potential therapeutic target for atherosclerosis

Zhao, Y.

Citation

Zhao, Y. (2011, November 1). Reverse cholesterol transport : a potential therapeutic target for atherosclerosis. Retrieved from https://hdl.handle.net/1887/18008

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/18008

Note: To cite this publication please use the final published version (if applicable).

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Stellingen

Reverse Cholesterol Transport

a potential therapeutic target for atherosclerosis

1. Both ABCA1 and SR-BI are essential for HDL-mediated reverse cholesterol transport (this thesis).

2. ABCA1-mediated HDL biogenesis is atherogenic when hepatic SR-BI is absent (this thesis).

3. The synergistic interaction of macrophage ABCA1 and SR-BI are more important for prevention of advanced atherosclerotic lesions rather than for the development of early atherosclerotic lesions (this thesis).

4. The expression of the LDL receptor is not required for the atheroprotective function of leukocyte ABCA1 (this thesis).

5. The beneficial effects of reconstituted HDL on atherosclerotic lesion development are partially caused by its phosphatidylcholine component (this thesis).

6. Hepatic SR-BI determines the atheroprotective effects of HDL elevation by inducing overexpression of ABCA1 in liver (Feng Y, Cardiovasc Res. 2010; 88: 376-85).

7. The cholesterol efflux capacity of HDL does not necessarily reflect the atheroprotective efficiency of HDL (Undurti A, J Biol Chem. 2009; 284: 30825-35).

8. Intracellular trafficking of free cholesterol not only influences cellular cholesterol homeostasis but also plays an important role in cell signaling pathways linked to cell function (Yvan-Charvet L, Science. 2010; 328: 1689-93; Koseki M, J Lipid Res.

2007; 48: 299-306).

9. The suppressive function of SR-BI in leukocyte proliferation contributes to its anti- atherogenic effects (Feng H, Arterioscler Thromb Vasc Biol. 2011; in press).

10. Stress should be prevented at all times as it leads to the waste of energy and distraction of attention.

11. After becoming a mother, you have to be efficient in your scientific work in order to reach home in time.

12. Good social collaboration skills are important for a successful scientific career.

13. Fighting with the reviewer inspires your research and improves the quality of your paper.

Ying ZHAO

28-09-2011, Leiden

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