To fail or not to fail : clinical trials in depression Sante, G.W.E.

LOCF has either reduced power or an inflated type I error, especially when dropout rates are unequal for active and placebo treatment and total dropout rate is high (as in study 2)..

Using his- torical clinical trial data, we evaluate in an integrated manner the impact of (a) sample size (number of patients), (b) randomisation ratio across treatment arms,

Overall, the use of the proposed adaptive design with reassessment of interim analysis criteria leads to substantial savings in terms of the number of patients required for the

In the clinical trial simulation re- ported in chapter 9, we have investigated the effect of the following design features on statistical power and false positive rate: (a) sample

Hierbij is gekeken naar (a) de grootte van de steekproef (het aantal patiënten), (b) de invloed van ongelijke randomisatie over de verschillende behan- delingen, (c) het aantal

In 2004 Gijs started his PhD research programme at the division of Pharmacology of the Leiden-Amsterdam Center for Drug Research in Leiden, with Dr Oscar Della Pasqua as co-promoter

Zoals de nauwkeurigheid van voorspellingen van depressies in het klimaat afhangt van de variabiliteit van het klimaat (Science, 318:582-583, 2007), wordt ook de nauw- keurigheid van

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in