University of Groningen
Pemphigoid diseases: Insights in the nonbullous variant and disease management Lamberts, Aniek
DOI:
10.33612/diss.132159641
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Lamberts, A. (2020). Pemphigoid diseases: Insights in the nonbullous variant and disease management. University of Groningen. https://doi.org/10.33612/diss.132159641
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Pemphigoid diseases: insights in the
nonbullous variant and disease management
ISBN: 978-94-034-2431-6
ISBN: 978-94-034-2430-9 (e-book)
©Copyright M.A. Lamberts 2020, the Netherlands
All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying,
recording, or by any information storage or retrieval system, without written permission of the author. The copyright of previously published chapters of this thesis remains with the publisher or journal.
Financial support for the publication of this thesis was provided by:
nanoString, Eurocept, Rijksuniversiteit Groningen, Studiefonds Dermatologie, Universitair Medisch Centrum Groningen.
Cover design: Martijn O. Wolf – MOTTOW – mottow.nl Interior design: Aniek Lamberts
Pemphigoid diseases: insights in the
nonbullous variant and disease management
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op dinsdag 22 september 2020 om 11.00 uur
door
Marlou Aniek Lamberts geboren op 17 juli 1990
Promotores Dr. B. Horváth Prof. dr. M.F. Jonkman† Copromotor Dr. H.H. Pas Reading committee Prof. dr. P. Heeringa Prof. dr. M.A. de Rie Prof. dr. R. Ludwig
Paranimfen Lisette Prens Angelique Rondags
Table of contents
Chapter 1 Introduction in pemphigoid diseases 9
PART 1
Nonbullous pemphigoid: disease characteristics
and immunological aspects
Chapter 2 Significantly higher prevalence of circulating bullous 35 pemphigoid-specific IgG autoantibodies in elderly
patients with a nonbullous skin disorder
Chapter 3 Nonbullous pemphigoid: a systematic review 43
Chapter 4 Nonbullous pemphigoid: insights in clinical and 61 diagnostic findings, treatment response and prognosis
Chapter 4A Reply to: “Pruritus with pemphigoid autoantibodies 81 is the tip of an iceberg”
Chapter 5 Prevalence of pemphigoid as a potentially unrecognized 85 cause of pruritus in nursing home residents
Chapter 6 IgE autoantibodies in serum and skin of nonbullous and 93 bullous pemphigoid patients
Chapter 7 Gene expression profile of lesional skin in bullous and 111 nonbullous pemphigoid: an explorative pilot study
PART 2
Management of pemphigoid diseases
Chapter 8 Unmet needs in pemphigoid diseases: an international 133
survey amongst patients, clinicians and researchers Chapter 9 Effectiveness and safety of rituximab in recalcitrant 147
pemphigoid diseases Chapter 10 Determining the incidence of pneumocystis pneumonia 171
in patients with autoimmune blistering diseases not receiving routine prophylaxis Chapter 11 Discussion and future perspectives 185
Chapter 12 Summary 209
Chapter 13 Samenvatting 217
Appendices Dankwoord 226
List of publications 228
