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University of Groningen Neurobiological determinants of depressive-like symptoms in rodents Bove, Maria

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University of Groningen

Neurobiological determinants of depressive-like symptoms in rodents

Bove, Maria

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Bove, M. (2018). Neurobiological determinants of depressive-like symptoms in rodents: A multifactorial approach. University of Groningen.

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Neurobiological determinants

of depressive-like symptoms

in rodents

Maria Bove

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The research presented in this thesis was performed at the Department of Physiology and Pharmacology “V. Erspamer” of the “Sapienza” University of Rome, Italy, in collaboration with the Department of Clinical and Experimental Medicine of the University of Foggia, Italy, and at the Groningen Institute for Evolutionary Life Sciences (GELIFES) of the University of Groningen, The Netherlands. The research was financially supported by “Sapienza” University of Rome, by PRIN 2011, by PRIN 2015 and by the PRISM project. The PRISM project (www.prism-project.eu) has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115916. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA. This publication reflects only the authors' views neither IMI JU nor EFPIA nor the European Commission are liable for any use that may be made of the information contained therein.

The printing of this thesis was financially supported by the Graduate school of Science and Engineering of the Faculty of Science and Engineering.

Printed by: Ridderprint BV | www.ridderprint.nl ISBN: 978-94-6299-866-7

ISBN: 978-94-6299-868-1 (electronic version)

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Neurobiological determinants of

depressive-like symptoms in rodents

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans

and

to obtain the degree of PhD at the “Sapienza” University of Rome

on the authority of the Rector Magnificus Prof. E. Gaudio

and in the accordance with the decision by the College of Deans

Double PhD degree

This thesis will be defended in public on Friday 9 February 2018 at 16.15 hours

by

Maria Bove

born on 27 May 1989 in Marsicovetere, Italy

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Supervisors

Prof. M.J.H. Kas Prof. V. Cuomo

Assessment Committee

Prof. E.A. van der Zee Prof. G. van Dijk Prof. M.A. Sortino Prof. L. Steardo

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A Saverio

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TABLE OF CONTENTS

CHAPTER 1

page 9

General Introduction

CHAPTER 2

page 23

Effects of n-3 PUFA enriched and n-3 PUFA deficient diets in naïve and

Aβ-treated female rats

CHAPTER 3

page 43

Detrimental effects of lifelong n-3 PUFA deficiency on stress- and

anxiety-related parameters in female rat offspring

CHAPTER 4

page 61

The Visible Burrow System: a behavioural paradigm to assess sociability

and social withdrawal in BTBR and C57BL/6J mice strains

CHAPTER 5

page 85

Studying social group behaviours in Pcdh9 deficient mice using the

Visible Burrow System

CHAPTER 6

page 103

General Discussion

REFERENCES

page 113

ENGLISH SUMMARY

page 131

NEDERLANDSE SAMENVATTING

page 135

SOMMARIO

page 141

ACKNOWLEDGEMENTS

page 145

LIST OF PUBBLICATIONS

page 149

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