Mechanism-based pharmacokinetic-pharmocodynamic modelling of opioids : role of biophase distribution and target interaction kinetics

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in

This model consists of two sequential effect compartments (i.e. a shallow and a deep effect compartment) and two rate constants for transport through the transfer compartment

Subsequent analysis with the operational model of agonism was performed with the values of the system maximum Em (123 μV) and n (1.44) constrained to the values of alfentanil

However, there were clear indications for two (sub-)populations of opioids. The estimated in vivo pK A for alfentanil, fentanyl and sufentanil were similar to the values obtained

Eerst werd de invloed van biofase distributie kinetiek in kaart gebracht (hoofdstuk 7). Met uitzondering van alfentanil werd voor alle opiaten een significante hysterese

Roel, zonder jouw hulp had mijn proefschrift er nu niet zo mooi uitgezien. En tot slot, lieve Michiel, zonder jouw onvoorwaardelijke liefde, steun en hulp had ik het

De passieve permeabiliteit, zoals bepaald kan worden in in vitro celsystemen, heeft een voorspellende waarde voor het transport naar de biofase in vivo.. Grote

Blades and blade fragments seem to have been especially used for longitudinal motions, mainly on plant material (7/12). Flake and flake fragments are used in different motions on