Novel experimental therapies for atherosclerosis : a genomics based
approach
Wanrooij, E.J.A. van
Citation
Wanrooij, E. J. A. van. (2007, September 26). Novel experimental therapies for
atherosclerosis : a genomics based approach. Retrieved from
https://hdl.handle.net/1887/12357
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/12357
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Novel Experimental Therapies for Atherosclerosis
A Genomics Based Approach
Novel Experimental Therapies for Atherosclerosis
A Genomics Based Approach
PROEFSCHRIFT
Ter verkrijging van
De graad van Doctor aan de Universiteit Leiden,
Op gezag van de Rector Magnificus Prof. Mr. P.F. van der Heijden, Volgens besluit van het College voor Promoties
Te verdedigen op woensdag 26 september Klokke 13.45
Door
Eva Josephine Anna van Wanrooij
Geboren te Weert in 1979
Promotiecommissie
Promotor: Prof. Dr. Th. J. C. van Berkel
Co-Promotor: Dr. J. Kuiper
Referent: Prof. Dr. J. Nilsson (Lund University)
Overige leden: Prof. Dr. M. Danhof
Prof. Dr. M.J.A.P Daemen (Universiteit Maastricht)
Dr. A.J. Horrevoets (Universiteit van Amsterdam)
The studies described in this thesis were financially supported by a grant of the Netherlands scientific Research Foundation (NWO) and were performed at the division of Biopharmaceutics, Leiden / Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands. Financial support by the Netherlands Heart Foundation for publication of this thesis is gratefully acknowledged.
Printing of this thesis was kindly supported by:
J. E. Jurriaanse stichting LACDR
Boehringer Ingelheim Universiteit Leiden
Printing:
ISBN: 978-90-9022085-7
Van Wanrooij, Eva Josephine Anna
Novel Experimental Therapies for Atherosclerosis; A Genomics Based Approach Proefschrift Leiden
Met literatuur opgave - Met samenvatting in het Nederlands
© 2007 EJA van Wanrooij
No part of this thesis may be reproduced or transmitted in any form or by any means, without permission of the author.
Table of Contents
Page
9 Chapter 1
General Introduction
43 Chapter 2
Transcriptional Profiling of Initial Atherogenesis in LDL Receptor Deficient Mice Identifies Diet Induced Upregulation of FOXO1 Controlled Genes Manuscript in preparation
59 Chapter 3
Transcriptional Profiling of CD4+ T cells During Diet Induced Atherogenesis Manuscript in preparation
75 Chapter 4
The HIV Entry Inhibitor TAK-779 Attenuates Atherosclerotic Plaque Formation in LDL Receptor Deficient Mice Arterioscler Thromb Vasc Biol.
2005 Dec;25(12):2642-7
91 Chapter 5
The CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic Plaque Formation in LDL Receptor Deficient Mice Conditionally accepted Arterioscler Thromb Vasc Biol.
107 Chapter 6
Vaccination Against CD99 Inhibits Atherogenesis in LDL Receptor Deficient Mice Submitted
123 Chapter 7
Vaccination against IL-16 Accelerates Atherogenesis in LDL Receptor Deficient Mice Manuscript in preparation
137 Chapter 8
Interruption of the OX40/OX40L Pathway Attenuates Atherogenesis in LDL Receptor Deficient Mice Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):204- 10
153 Chapter 9
CD127 is Required for Macrophage and Regulatory T cell Function and Has a Protective Role in Atherosclerosis Manuscript in preparation
169 Chapter 10
Summary and Future Perspectives
179 Nederlandse Samenvatting
185 Curriculum Vitae
186 List of Publications
190 Appendix 1: Table of PCR primers
192 Appendix 2: List of abbreviations
