Lifestyle and venous thrombosis
Pomp, E.R.
Citation
Pomp, E. R. (2008, December 3). Lifestyle and venous thrombosis. Retrieved from https://hdl.handle.net/1887/13308
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13308
Note: To cite this publication please use the final published version (if applicable).
Lifestyle and venous thrombosis
Elisabeth R. Pomp
Cover photo: Vino by Gabriel Gonzalez G.
Cover design: Elisabeth Pomp
ISBN: 978-90-8559-455-0
Printed by Optima Grafische Communicatie, Rotterdam, The Netherlands
Lifestyle and venous thrombosis
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties
te verdedigen op woensdag 3 december 2008
klokke 15.00 uur door
Elisabeth Rebekka Pomp
geboren te Hoogeveenin 1980
PROMOTIECOMMISSIE
Promotor: Prof. Dr. F.R. Rosendaal
Copromotor: Dr. C.J.M. Doggen
Referent: Prof. Dr. H.R. Büller (University of Amsterdam)
Overige leden: Prof. Dr. P.M.M. Bossuyt (University of Amsterdam) Prof. Dr. P.H. Reitsma
Dr. S. le Cessie
Prof. Dr. F.M. Helmerhorst
The work described in this thesis was performed at the department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. The MEGA study was supported by the Netherlands Heart Foundation (NHS 98.113), the Dutch Cancer Foundation (RUL 99/1992) and the Netherlands Organisation for Scientific Research (912-03-033| 2003).
Financial support by the Netherlands Heart Foundation and the J.E. Jurriaanse Stichting for publication of this thesis is gratefully acknowledged.
Table of contents
Chapter 1 General introduction 7
Chapter 2 Risk of venous thrombosis: obesity and its joint effect with oral contraceptive use and prothrombotic mutations
17
Chapter 3 Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use
35
Chapter 4 Alcohol consumption is associated with a decreased risk of venous thrombosis
51
Chapter 5 Pregnancy, the postpartum period and prothrombotic defects:
risk of venous thrombosis in the MEGA study
63
Chapter 6 Polymorphisms in the protein C gene as risk factor for venous thrombosis
77
Chapter 7 The experience of multiple control groups in a large case- control study on gene-environment interaction
91
Chapter 8 Discussion and summary 107
Samenvatting 117
Dankwoord 123
Curriculum Vitae 125
