Citation
Vries, J. F. de. (2008, June 25). Complexity of apoptotic pathways in leukemia treated with chemotherapy or cellular immunotherapy.
Retrieved from https://hdl.handle.net/1887/12980
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University of Leiden
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Complexity of apoptotic pathways in leukemia treated with chemotherapy or cellular
immunotherapy
Complexity of apoptotic pathways in leukemia treated with chemotherapy or cellular
immunotherapy
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 25 juni 2008
klokke 15.00 uur
door
Jeltje Froukje de Vries geboren te Veenwouden
in 1977
Prof. Dr. P.C.W. Hogendoorn
Prof. Dr. M.H. van Oers, Universiteit van Amsterdam
Cover : J. de Jong, T. van Os Lay-out : M. IJdo-Reintjes, W. Netten
Printing : Ridderprint Offsetdrukkerij B.V., Ridderkerk
The work described in this thesis and the printing of this thesis were financially supported by the Dutch Cancer Society (KWF).
... en huorre, huorre, huorre, de baarch is yn ‘e skuorre (ύt: “Der wie ris in âld wyfke” fan Nynke van Hichtum, 1860-1939)
Foar heit en mem
TABLE OF CONTENTS
Chapter 1 General Introduction 9
Chapter 2 The mechanisms of Ara-C-induced apoptosis of resting 33 B-chronic lymphocytic leukemia cells
Haematologica 91(7): 912-919, 2006
Chapter 3 Involvement of caspase-8 in chemotherapy-induced 51
apoptosis of patient derived leukemia cell lines independent of the death receptor pathway and downstream from mitochondria Apoptosis 12(1): 181-193, 2007 Chapter 4 Differential activation of the death receptor pathway in 71 human target cells induced by cytotoxic T lymphocytes showing different kinetics of killing Haematologica 92(12): 1671-1678, 2007 Chapter 5 The Granzyme B-binding serpin PI-9 interferes with 87
Fas-induced apoptosis: implications for interpretation of prognostic factors in relation to therapy of cancer Chapter 6 Cytotoxic T cells induce target cell death via an MHC- 93 restricted granule-mediated and a non MHC-restricted death-receptor-mediated mechanism of killing Submitted Chapter 7 Summary and General Discussion 109
Samenvatting 127
List of Abbreviations 137
Dankwoord 139
Curriculum Vitae 141
