Cover Page
The handle
http://hdl.handle.net/1887/138093
holds various files of this Leiden University
dissertation.
Author:
Mulder, I.A.
Title: Stroke and migraine: Translational studies into a complex relationship
Issue Date:
2020-11-05
STROKE & MIGRAINE
Inge Mulder
STROKE & MIGRAINE - Transla onal studies into a complex rela onship PhD Thesis, Leiden University, Leiden, the Netherlands, 2020
Cover design & layout: Inge Mulder. Human brain picture by courtesy of Prof. dr. Rozemuller. Prin ng: Ridderprint | www.ridderprint.nl
ISBN: 978-94-6416-162-5 © Inge Mulder, 2020
Copyright of published material in chapters 2-5,7 and 8 lies with the publisher of the journal listed at the tlepage of each chapter. No part of this thesis may be reproduced in any form, by print, photocopy, digital fi le, internet or any other means without wri en permission of the copyright holder.
STROKE MIGRAINE
P
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnifi cus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promo es
te verdedigen op donderdag 5 november 2020
klokke 13:45 uur
door
I
M
Geboren te Oosterhout, Nederland
In 1986
Promotores
Prof. Dr. A.M.J.M. van den Maagdenberg Prof. Dr. M.J.H. Wermer
Prof. Dr. M.D. Ferrari
Leden promo ecommissie
Prof. Dr. R.M. Dijkhuizen UMC Utrecht
Prof. Dr. M. Hoehn Max-Planck Ins tute, DU Prof. Dr. J. Verschuuren
Prof. Dr. H.E. de Vries Amsterdam UMC – VUmc
The research described in this thesis was supported by a grant of the Dutch Heart Founda on (DHF 2011T055). Other acknowledged funding is listed at the end of each chapter. Prin ng of this thesis was supported by the Dutch headache society (NHV - Nederlandse hoofdpijn vereniging) and also the fi nancial support by the Dutch Heart Founda on for publica on of this thesis is gratefully acknowledged.
T
C 1 9
General introduc on PART I
C 2 25
Funnel-freezing versus heat-stabiliza on for the visualiza on of metabolites by mass spectrometry imaging in a mouse stroke model
C 3 39
Dis nguishing core from penumbra by lipid profi les using mass spectrometry imaging in mice a er experimental infarct induc on
C 4 69
Automated ischemic lesion segmenta on in MRI mouse brain data a er transient middle cerebral artery occlusion
&
MRI mouse brain data of ischemic lesion a er transient middle cerebral artery occlusion
C 5 91
Increased mortality and vascular phenotype in a knock-in mouse model of re nal vasculopathy with cerebral leukoencephalopathy and systemic manifesta ons
C 6 111
Comparing characteris cs of spreading depolariza on and ischemic stroke in transgenic mouse models of various monogenic disorders relevant to migraine and stroke
PART II
C 7 127
Stroke progression and clinical outcome in ischemic stroke pa ents with a history of migraine
C 8 143
Migraine and cerebrovascular atherosclerosis in pa ents with ischemic stroke
C 9 155
General discussion
A 171
Summary
Nederlandse samenva ng List of publica ons Curriculum vitae Dankwoord
