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Cover Page The handle http://hdl.handle.net/1887/47852 holds various files of this Leiden University dissertation Author: Niemeijer, N.D. Title: Paragangliomas: Clinical Picture Issue Date: 2017-03-29

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Cover Page

The handle http://hdl.handle.net/1887/47852 holds various files of this Leiden University dissertation

Author: Niemeijer, N.D.

Title: Paragangliomas: Clinical Picture

Issue Date: 2017-03-29

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PARAGANGLIOMAS:

CLINICAL PICTURE

Nicolasine D. Niemeijer

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Paragangliomas: clinical picture Nicolasine Diana Niemeijer

ISBN: 978-94-6299-538-3

Copyright © Nicolasine Diana Niemeijer, 2017

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system of any nature, or transmitted in any form or by any means without permission of the author.

Layout: Nikki Vermeulen | Ridderprint BV Printing: Ridderprint BV | www.ridderprint.nl

Financial support for this thesis was generously provided by:

Raad van Bestuur IJsselland Ziekenhuis (Capelle aan den IJssel) and Goodlife Healthcare BV.

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PARAGANGLIOMAS:

CLINICAL PICTURE

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op woensdag 29 maart 2017

klokke 15.00 uur

door

Nicolasine Diana Niemeijer geboren op 17 februari 1981

te Gouda

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Promotor: Prof. dr. A.M. Pereira

Co-promotor: dr. E.P.M. van der Kleij-Corssmit

Leden promotiecommissie: Prof. dr. T.P. Links (UMCG, Groningen) Prof. dr. E.J.P. de Koning

Prof. dr. J.A. Romijn (AMC, Amsterdam) Prof. dr. J. Morreau

Dr. J.C. Jansen

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Voor mijn ouders

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CONTENTS

Chapter 1 General introduction 9

Chapter 2 Low penetrance of paraganglioma and pheochromocytoma 25 in an extended kindred with a germline SDHB exon 3 deletion

Chapter 3 The phenotype of SDHB germline mutation carriers; 37 a nationwide study

Chapter 4 Succinate dehydrogenase (SDH)-deficient pancreatic 59 neuroendocrine tumor expands the SDH-related

tumor spectrum

Chapter 5 Sleep-mediated heart rate variability after bilateral carotid 79 body tumor resection

Chapter 6 131I-MIBG therapy for malignant paraganglioma and 95 pheochromocytoma: systematic review and meta-analysis

Chapter 7 Chemotherapy with cyclofosfamide, vincristine and 123 dacarbazine for malignant paraganglioma and

pheochromocytoma: systematic review and meta-analysis

Chapter 8 Summary and conclusions 143

Chapter 9 Nederlandse samenvatting 153

Appendix Curriculum Vitae 165

List of publications 169

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