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A multidisciplinary lifestyle intervention for childhood obesity : effects on body composition, exercise tolerance, quality of life and gut hormones

Vos, R.C.

Citation

Vos, R. C. (2011, April 7). A multidisciplinary lifestyle intervention for

childhood obesity : effects on body composition, exercise tolerance, quality of life and gut hormones. Retrieved from https://hdl.handle.net/1887/16698

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/16698

Note: To cite this publication please use the final published version (if applicable).

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Rimke C. Vos

A Multidisciplinary Lifestyle Intervention for Childhood Obesity:

Effects on body composition, exercise tolerance,

quality of life and gut hormones

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A Multidisciplinary Lifestyle Intervention for Childhood Obesity:

Effects on body composition, exercise tolerance, quality of life and gut hormones

© Rimke C. Vos

2011 Den Haag ISBN: xxx-xx-xxxxxxx-x Pre-press

De VormCompagnie, Houten Printing

Drukkerij xxxxxxxxx

Financiële ondersteuning druk proefschrift:

HagaZiekenhuis, Den Haag Ipsen Farmaceutica B.V., Hoofddorp Pfizer BV, Capelle aan de IJssel

De studies beschreven in dit proefschrift zijn mede mogelijk gemaakt door ontvangst van een unrestricted educational grant van Pfizer BV en een unrestricted educational grant ontvangen van de non-profit stichting de ‘Stichting Vrienden van het JKZ’.

Promotiereeks HagaZiekenhuis

Het HagaZiekenhuis van Den Haag is trots op medewerkers die fundamentele bijdragen leveren aan de wetenschap en stimuleert hen daartoe. Om die reden biedt het HagaZiekenhuis promovendi de mogelijkheid hun dissertatie te publiceren in een speciale Haga uitgave, die onderdeel is van de promotiereeks van het HagaZiekenhuis.

Daarnaast kunnen promovendi in het wetenschaps magazine HagaScoop van het ziekenhuis aan het woord komen over hun promotieonderzoek.

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Proefschrift ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op donderdag 7 april 2011

klokke 15:00 uur

Door:

Rimke Cathelijne Vos geboren te Delft

in 1982

A Multidisciplinary Lifestyle Intervention for Childhood Obesity:

Effects on body composition, exercise tolerance,

quality of life and gut hormones

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Promotiecommissie:

Promotoren: Prof. dr. J. M. Wit Prof. dr. H. Pijl Copromotor: Dr. E.C.A. M. Houdijk

Overige leden: Prof. dr. H. A. Delemarre-van de Waal Prof. dr. A. A. Kaptein

Dr. I.M.Jazet

Dr. E.L.T.van den Akker (ErasmusMC, Rotterdam)

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“Wees volwassen, maar blijf altijd een beetje kind” (mijn vader)

Opdracht: voor David, mijn ouders en Floris

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Contents

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Chapter 1 General introduction 8 Chapter 2 The effect of family-based multidisciplinary

cognitive behavioral treatment in children with obesity: study protocol for a randomized controlled trial

14

Chapter 3 Long-term effect of Lifestyle Intervention on Adiposity, Metabolic Parameters, Inflammation and Physical Fitness in obese children:

a randomized controlled trial

38

Chapter 4 The Effect of Multidisciplinary Lifestyle Intervention on the Pre- and Postprandial Plasma Gut Peptide Concentrations in Children with Obesity

58

Chapter 5 The effect of family-based multidisciplinary cognitive behavioral treatment on Health Related Quality of Life in Childhood Obesity

74

Chapter 6 The Predictive Value of the Individual Components of the Metabolic Syndrome for Insulin Resistance in Obese Children

90

Chapter 7 General Discussion 108

Chapter 8 Summary 118

Chapter 9 Samenvatting 127

Dankwoord 129

Curriculum Vitae 131

List of publications 132

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