Cover Page
The handle https://hdl.handle.net/1887/3160747 holds various files of this Leiden University dissertation.
Author: Zunder, S.M.
Title: Exploring prognostic and predictive application of the tumor-stroma ratio in colorectal cancer
Issue Date:
2021-04-15Exploring prognostic and predictive application of the tumor-stroma ratio in colorectal cancer
Stéphanie Marleen Zunder
COLOPHON
Exploring prognostic and predictive application of the tumor-stroma ratio in colorectal cancer by Stéphanie Zunder
ISBN: 978-94-6416-207-3
Cover design and lay-out: Elisa Calamita, persoonlijkproefschrift.nl Printing: Ridderprint | www.ridderprint.nl
© S.M. Zunder, 2021, Leiden, The Netherlands
All rights reserved. No part of this thesis may be reproduced or transmitted in any form, by any means, electronic or mechanical without prior permission of the author.
Exploring prognostic and predictive application of the tumor-stroma ratio in colorectal cancer
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden, op gezag van rector magnificus prof.dr.ir. H. Bijl,
volgens besluit van het college voor promoties te verdedigen op donderdag 15 april 2021
klokke 10.00 uur
door
Stéphanie Marleen Zunder geboren te Willemstad (Curaçao)
in 1987
Exploring prognostic and predictive application of the tumor-stroma ratio in colorectal cancer
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden, op gezag van rector magnificus prof.dr.ir. H. Bijl,
volgens besluit van het college voor promoties te verdedigen op donderdag 15 april 2021
klokke 10.00 uur
door
Stéphanie Marleen Zunder geboren te Willemstad (Curaçao)
in 1987
Promotores
Prof. dr. A. J. Gelderblom Prof. dr. R.A.E.M. Tollenaar Co-promoter
Dr. W.E. Mesker Promotiecommissie Prof. dr. J.E.A. Portielje
Prof. dr. G.L. Beets (Antoni van Leeuwenhoek, NKI, Amsterdam) Prof. dr. J.H.J.M. van Krieken (Radboud Universiteit, Nijmegen)
TABLE OF CONTENTS Chapter 1
General introduction and outline 7
Chapter 2
The significance of stromal collagen organization in cancer tissue: an in-depth discussion of literature
Critical Reviews in Oncology Hematology 2020 Jul;151:102907
19
Chapter 3
Stromal organization as predictive biomarker for the treatment of colon cancer with adjuvant bevacizumab; a post-hoc analysis of the AVANT trial Cellular Oncology 2019 Oct;42(5):717-725
61
Chapter 4
Predictive potential of tumor-stroma ratio on benefit from adjuvant bevacizumab in high-risk stage II and stage III colon cancer British Journal of Cancer 2018 Jul;119(2):164-169
83
Chapter 5
Prognostic and predictive value of tumor-stroma ratio in stage II colorectal cancer
107
Clinal Oncology and Research 2020 Apr;3(4): 3-8 Chapter 6
Correlation of the tumor-stroma ratio with diffusion weighted MRI in rectal cancer
125
European Journal of Radiology 2020, Oct:109345 Chapter 7
Summary, general discussion and future perspectives 143
Chapter 8 153
Nederlandse samenvatting Appendices
List of publications, author affiliations, curriculum vitae, dankwoord 161
