• No results found

Massive deep-frozen bone allografts : contamination, immunogenicity and clinical use

N/A
N/A
Protected

Academic year: 2021

Share "Massive deep-frozen bone allografts : contamination, immunogenicity and clinical use"

Copied!
5
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)Massive deep-frozen bone allografts : contamination, immunogenicity and clinical use Deijkers, Ruud. Citation Deijkers, R. (2005, January 18). Massive deep-frozen bone allografts : contamination, immunogenicity and clinical use. Retrieved from https://hdl.handle.net/1887/3765 Version:. Corrected Publisher’s Version. License:. Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded from:. https://hdl.handle.net/1887/3765. Note: To cite this publication please use the final published version (if applicable)..

(2) . *OHW[LY. :\TTHY`HUKJVUJS\ZPVUZ.

(3) ððñ$IBQUFSö. 4VNNBSZBOEDPODMVTJPOT. ɨJTUIFTJTBEESFTTFTBOVNCFSPGQSPCMFNTBOEDPOUSPWFSTJFTSFHBSEJOH UIFVTFPGNBTTJWFEFFQGSP[FOCPOFBMMPHSBGUTɨFTUVEJFTEFTDSJCFEJO UIJTUIFTJTJOWPMWFUPQJDTPOCBDUFSJBMDPOUBNJOBUJPO DIBQUFSñ JNNVOP HFOJDJUZ DIBQUFSò BOEDMJOJDBMVTFPGNBTTJWFEFFQGSP[FOCPOFBMMPHSBGUT DIBQUFSTó ô õ . *O DPODMVTJPO EFTQJUFDBSFGVMEPOPSTFMFDUJPOBOEBTFQUJDUJTTVFQSP  DVSFNFOU DPOUBNJOBUJPOJTGSFRVFOUɨFNBKPSTPVSDFPGDPOUBNJOB  UJPOJTFYPHFOPVT MPXQBUIPHFOJDTLJODPNNFOTBMT BOEJTTUSPOHMZ JOnVFODFECZUIFQSPDVSFNFOUUFBN$POUBNJOBUJPOGSPNFOEPHFOPVT TPVSDFT IJHIQBUIPHFOJDDPOUBNJOBOUTPGUIFHBTUSPJOUFTUJOBMUSBDU DBO CFDPOUSPMMFECZEPOPSTFMFDUJPO&YDMVTJPOPGEPOPSTXJUITFWFSFUSBVNB JOIJHIMZDPMPOJTFEBSFBTDBOEJNJOJTIUIFFOEPHFOPVTDPOUBNJOBUJPO. *O$IBQUFSì BTIPSUIJTUPSZPGUIFUSBOTQMBOUBUJPOPGNBTTJWFGSP[FOCPOF BMMPHSBGUJTQSFTFOUFE BOEUIFQSJODJQBMBEWBOUBHFTBOEEJTBEWBOUBHFTPG UIFTFUSBOTQMBOUBUJPOTBSFEJTDVTTFE%FTQJUFUIFMPOHUFSNVTFBOEXPSME XJEFTUVEJFT RVFTUJPOTBOEDPOUSPWFSTJFTBSPVOEUIFVTFPGNBTTJWFEFFQ GSP[FOCPOFBMMPHSBGUTTUJMMFYJTU"OVNCFSPGQSPCMFNTBOEDPOUSPWFSTJFT BSFTQFDJmFEBOEQSFTFOUFE #BTFEPOUIFTFTQFDJmFEQSPCMFNTBOEDPOUSPWFSTJFT UIFBJNPGUIJT UIFTJTXBTEFmOFEBOEUIFTUVEJFTUIBUBJNUPTPMWFUIFTFQSPCMFNTBOE DPOUSPWFSTJFTXFSFPVUMJOFE0OFTUVEZBEESFTTFEUIFCBDUFSJBMDPO  UBNJOBUJPOPGBMMPHSBGUTSFUSJFWFEGSPNQPTUNPSUBMEPOPST BOPUIFSPOF BEESFTTFEUIFJNNVOPHFOJDJUZPGUSBOTQMBOUFEBMMPHSBGUT BOEUISFFTUVE  JFTBEESFTTFEUIFJOEJDBUJPOTBOEPQFSBUJWFUFDIOJRVFTPGUISFFMFTTDPN  NPOUZQFTPGBMMPHSBGUSFDPOTUSVDUJPOT *O $IBQUFSí XFBOBMZTFEUIFCBDUFSJBMDPOUBNJOBUJPOPGðøøøCPOF BMMPHSBGUTSFUSJFWFEGSPNñïïDBEBWFSEPOPSTVOEFSTUFSJMFDPOEJUJPOT" NVMUJWBSJBUFBOBMZTJTVTJOHBNVMUJQMFMPHJTUJDSFHSFTTJPONPEFMXBTQFS  GPSNFEUPmOEQPUFOUJBMSJTLGBDUPSTGPSDPOUBNJOBUJPO*EFOUJGZJOHUIFTF SJTLGBDUPSTIFMQFEUPmOENFUIPETUPEFDSFBTFUIFSBUFPGDPOUBNJOBUJPO BOEJODSFBTFUIFBWBJMBCJMJUZBOETBGFUZPGUIFBMMPHSBGUT'VSUIFSNPSF UIF FĊFDUJWFOFTTPGSJOTJOHUIFBMMPHSBGUTXBTBTTFTTFE 0SHBOJTNTPGMPXQBUIPHFOJDJUZXFSFDVMUVSFEGSPNôïǷPGUIFHSBGUT BOEPGIJHIQBUIPHFOJDJUZGSPNòǷɨFSJTLPGDPOUBNJOBUJPOXJUIMPX QBUIPHFOJDPSHBOJTNT NBJOMZTLJODPNNFOTBMT JODSFBTFECZBGBDUPSPG ðõGPSFBDIFYUSBNFNCFSBEEFEUPUIFQSPDVSFNFOUUFBNɨFSJTLPG DPOUBNJOBUJPOXJUIIJHIQBUIPHFOJDPSHBOJTNT NBJOMZDPOUBNJOBOUTPG UIFHBTUSPJOUFTUJOBMUSBDU XBTòóUJNFTIJHIFSJOEPOPSTXJUIBUSBVNBUJD DBVTFPGEFBUIBOEôñUJNFTIJHIFSJOUIPTFXJUIQPTJUJWFCMPPEDPOUBNJ  OBUJPO1SFDFEJOHPSHBOQSPDVSFNFOUEJEOPUTJHOJmDBOUMZJOnVFODFUIF SJTLPGDPOUBNJOBUJPO3JOTJOHUIFHSBGUXJUIBOBOUJCJPUJDTPMVUJPOXBT OPUBOFĊFDUJWFEFDPOUBNJOBUJPONFUIPE. ððò. *O$IBQUFSî XFBOBMZTFEUIFDFMMVMBSJNNVOFSFTQPOTFJOUFOUSBOTQMBO  UBUJPOTPGNBTTJWFGSP[FOCPOFBMMPHSBGUTɨFGSFRVFODZPGDJSDVMBUJOH DZUPUPYJD5MZNQIPDZUFT $5- BOE5IFMQFSMZNQIPDZUFT 5) EJSFDUFE BHBJOTUNJTNBUDIFEEPOPSBOUJHFOTXFSFEFUFSNJOFECZMJNJUJOHEJMVUJPO BOBMZTJT -%" BTTBZTɨFBċOJUZPGEPOPSTQFDJmD$5-BHBJOTUUIFNJT NBUDIFEEPOPSBOUJHFOTXBTEFUFSNJOFEPOUIFCBTJTPGUIFJSSFTJTUBODFJO WJUSPUPBOUJ$%÷ $5-BOE5)BHBJOTUNJTNBUDIFEEPOPSBOUJHFOTXFSFGPVOEJOUIF QFSJQIFSBMCMPPEPGBMMQBUJFOUT.PSFJNQPSUBOUMZ BOESFQPSUFEGPSUIF mSTUUJNF $5-XJUIIJHIBċOJUZGPSEPOPSBOUJHFOTXFSFGPVOEJOmWF QBUJFOUTɨFTFIJHIBċOJUZ$5-BSFUIFSFTVMUPGJOWJWPBDUJWBUJPOCZ EPOPSTQFDJmD)-"BOUJHFOTɨFZEPOPUOFFE$%÷NPMFDVMFTUPTUB  CJMJTFUIFBOUJHFOBOEBSFTUSPOHMZBTTPDJBUFEXJUISFKFDUJPOPGIFBSUBOE DPSOFBMUSBOTQMBOU&WFOBGUFSUIFSFNPWBMPGNPTUCPOFNBSSPXDFMMT XF GPVOEIJHIBċOJUZ$5-BOEIJHI5)GSFRVFODJFTɨJT5DFMMSFTQPOTF DPVMECFEFUFDUFEPWFSBQFSJPEPGZFBST *ODPODMVTJPO NBTTJWFGSP[FOCPOFBMMPHSBGUTDBOJOEVDFIJHIBċOJUZ EPOPSTQFDJmD$5-ɨFQSFTFOUBTTBZBMMPXTRVBMJmDBUJPOBOERVBOUJmDB UJPOPGUIFMFWFMTPG$5-BOE5)JOUIFCMPPE4JODFUIFDISPOJDSFKFDUJPO PGCPOFBMMPHSBGUTJTDPOTJEFSFEUPCFQSJNBSJMZNFEJBUFECZ5DFMMT XJUI BLFZSPMFGPSIJHIBċOJUZ$5-BOE5) PVSBQQSPBDINBZCFIFMQGVM JOFTUBCMJTIJOHUIFFĊFDUPGUIFJNNVOFSFTQPOTFPOUIFJODPSQPSBUJPOPG CPOFHSBGUT *O$IBQUFSï XFFWBMVBUFEUIFNFEJVNUFSNDMJOJDBMSFTVMUTPGIFNJDPSUJ DBMQSPDFEVSFTGPSTFMFDUFEDBTFTPGMPXHSBEFNBMJHOBOUCPOFUVNPVST -PXHSBEFUVNPVSTBSJTJOHJOPSOFBSUIFDPSUFYDBO UIFPSFUJDBMMZ CF SFTFDUFEXIJMFNBJOUBJOJOHBQBSUPGUIFDPSUJDBMDJSDVNGFSFODFɨFTFTP DBMMFEIFNJDPSUJDBMSFTFDUJPOTDBOJEFBMMZCFSFDPOTUSVDUFEXJUIBOJOMBZ.

(4) ððó$IBQUFSö. 4VNNBSZBOEDPODMVTJPOT. BMMPHSBGUɨFPODPMPHJDBMBOEBMMPHSBGUPVUDPNFTXFSFBOBMZTFEUPEFUFS  NJOFUIFFċDBDZBOETBGFUZPGUIJTUFDIOJRVF ɨFññDPOTFDVUJWFIFNJDPSUJDBMQSPDFEVSFTGPSMPXHSBEFQBSPTUFBM PTUFPTBSDPNBT QFSJQIFSBM TFDPOEBSZ DIPOESPTBSDPNBT BOEBEBNBOUJ  OPNBTTIPXFEHPPEPODPMPHJDBMBOEBMMPHSBGUPVUDPNFTɨFSFXBTOP FWJEFODFPGMPDBMSFDVSSFODFBOEEJTUBOUNFUBTUBTJTBUBNFBOGPMMPXVQ PGõóNPOUIT ñöUPðòô "MMBMMPHSBGUTJODPSQPSBUFEDPNQMFUFMZBOEUIFSF XFSFOPBMMPHSBGUGSBDUVSFTPSJOGFDUJPOT'SBDUVSFPGUIFIPTUTSFNBJOJOH DPSUFYPDDVSSFEJOTJYQBUJFOUT BMMCFGPSFJODPSQPSBUJPOPGUIFHSBGUXBT QSFTFOUɨFZXFSFNBOBHFETVDDFTTGVMMZCZDBTUPSPTUFPTZOUIFTJTɨF GVODUJPOBMSFTVMUTXFSFFYDFMMFOUPSHPPEJOBMMFYDFQUPOFQBUJFOUBOE DPNQBSFEGBWPVSBCMFUPMBSHFSJOUFSDBMBSZQSPDFEVSFT *ODPODMVTJPO IFNJDPSUJDBMQSPDFEVSFTGPSTFMFDUFEDBTFTPGMPXHSBEF TVSGBDFUVNPVSTHJWFFYDFMMFOUPODPMPHJDBMBOEBMMPHSBGUPVUDPNFT8JEF SFTFDUJPONBSHJOTDBOCFBDIJFWFE FWFOXIFOUIFNFEVMMBJTJOWPMWFE 1SFDJTFQSFPQFSBUJWFQMBOOJOHVTJOH.3*JTFTTFOUJBMUPEFmOFUIFNBSHJOT PGSFTFDUJPO"MUIPVHIUIFIFNJDPSUJDBMQSPDFEVSFJTUFDIOJDBMMZEFNBOE  JOH HSBUJGZJOHDMJOJDBMSFTVMUTNBLFJUDMFBSMZXPSUIXIJMFGPSTFMFDUFE QBUJFOUT. *ODPODMVTJPO BTUIFFQJEJBQIZTFBMSFDPOTUSVDUJPOCZQBTTFTDPNQMJDB  UJPOTBTTPDJBUFEXJUIKPJOUSFDPOTUSVDUJPOBOESFTVMUTBSFDPNQBSBCMFUP PUIFSUZQFTPGJOUFSDBMBSZBMMPHSBGUT UIJTUZQFPGSFDPOTUSVDUJPOTIPVME CFDPOTJEFSFEJGBUMFBTUðDNPGUVNPVSGSFFKVYUBBSUJDVMBSCPOFDBOCF NBJOUBJOFE"QJUGBMMPGUIJTSFDPOTUSVDUJPOJTUIFEJċDVMUmYBUJPOPGUIF FQJQIZTFBMHSBGUIPTUKVODUJPO-FOHUIPGUIFSFDPOTUSVDUJPODPSSFMBUFE OFHBUJWFMZXJUITVSWJWBMPGUIFJOUFSDBMBSZBMMPHSBGUT. *O $IBQUFSð XFDPNQBSFEUIFPVUDPNFTPGðóFQJEJBQIZTFBMJOUFSDB  MBSZSFDPOTUSVDUJPOTGPSNBMJHOBOUCPOFUVNPVSTBSPVOEUIFLOFFUPø NFUBEJBQIZTFBMBOEðñEJBQIZTFBMJOUFSDBMBSZSFDPOTUSVDUJPOTPGGFNVS BOEUJCJB*OUIFTFFQJEJBQIZTFBMJOUFSDBMBSZSFDPOTUSVDUJPOTðUPñDN PGUIFFQJQIZTJTXJUIBEIFSFOUKPJOUXBTMFGUJOQMBDF QSFTFSWBUJPOPGUIF KPJOUBWPJETUIFOFFEGPSKPJOUSFDPOTUSVDUJPOXJUIBTTPDJBUFEQSPCMFNT 'VSUIFSNPSF XFBOBMZTFESJTLGBDUPSTGPSHSBGUGBJMVSFBOEDPNQMJDBUJPOT "MMFQJQIZTFBMPTUFPUPNJFTIBEUVNPVSGSFFNBSHJOTBOEOPMPDBM SFDVSSFODFT ,BQMBO.FJFSBOBMZTJTTIPXFEBðïZFBSTVSWJWBMSBUFPGUIF FQJEJBQIZTFBMSFDPOTUSVDUJPOTPGö÷Ƿ XIJDIEJĊFSFEOPUTJHOJmDBOUMZ GSPNUIF÷øǷPGUIFNFUBEJBQIZTFBMBOEUIFöôǷPGUIFEJBQIZTFBMSFDPO TUSVDUJPOT&QJEJBQIZTFBMDPNQMJDBUJPOTJODMVEFEUXPJOGFDUJPOT mWF GSBDUVSFTBOEUISFFOPOVOJPOUSFBUNFOUT$PNQMJDBUJPOTGPSBMMòôHSBGUT JODMVEFEUISFFJOGFDUJPOT UXFMWFGSBDUVSFTBOEOJOFOPOVOJPOUSFBUNFOUT 6MUJNBUFMZTJYPGBMMHSBGUTGBJMFE JOGFDUJPOBOEMFOHUIPGSFTFDUJPOTXFSF TJHOJmDBOUQSFEJTQPTJOHGBDUPST&BDIUZQFPGJOUFSDBMBSZSFDPOTUSVDUJPO TIPXFEHPPEGVODUJPOBMSFTVMUTXJUINFBO.454TDPSFTCFUXFFOñòBOE ñó. ððô. *O$IBQUFSñ UIFNFEJVNUPMPOHUFSNSFTVMUTPGñïBMMPHSBGUQSPTUIFTJT DPNQPTJUFSFDPOTUSVDUJPOTPGUIFQSPYJNBMGFNVSXFSFFWBMVBUFE$POUSBSZ UPPUIFST PVSUFDIOJRVFDPNQSJTFEQSFTTmUmYBUJPOPGBMPOHTUFNQSPT  UIFTJTJOCPUIBMMPHSBGUBOEIPTUCPOFɨFTBMWBHFEHMVUFBMUFOEPOTXFSF TVUVSFEUPUIFDPSSFTQPOEJOHUFOEPOTPOUIFHSBGUBOEBCJQPMBSDVQXBT VTFEXIFOQPTTJCMFɨFSFTVMUTXFSFDPNQBSFEXJUIUIFSFQPSUFESFTVMUT PGPUIFSDPNQPTJUFUFDIOJRVFTBOENFHBQSPTUIFTJT (PPEIJQTUBCJMJUZBOEMPOHUFSNGVODUJPOXFSFGPVOEBGUFSUIFSFDPO TUSVDUJPOT/PEJTMPDBUJPOTPGUIFCJQPMBSDVQPDDVSSFE'PVSSFDPOTUSVD  UJPOTGBJMFE BOEUIFZXFSFDBVTFECZTUFNMPPTFOJOHPSTUFNGSBDUVSF *OPOFPGUIFTFBGSBDUVSFPGUIFHSBGUBMTPPDDVSSFEɨF,BQMBO.FJFS BOBMZTJTTIPXFEBðïZFBSTVSWJWBMSBUFPGõóǷGPSUIFTUFNBOE÷öǷGPS UIFHSBGUɨFTUFNGBJMVSFTDPVMECFBUUSJCVUFEUPUIFVTFPGBOVOEFSTJ[FE HSBGU BTNBMMEJBNFUFSTUFNBOESFTVMUBOUJOBEFRVBUFQSFTTmUmYBUJPOPG UIFTUFNJOUIFIPTUCPOF0ODFMPPTFOJOHPGUIFTUFNJOUIFIPTUCPOF IBEEFWFMPQFE MPPTFOJOHJOUIFHSBGUGPMMPXFEXJUIJOGPVSZFBSTɨFSFWJ TJPOTXFSFSFMBUJWFMZTJNQMFBTUIFOPOGSBDUVSFEHSBGUTDPVMECFMFGUJO QMBDF *O DPODMVTJPO UIFVTFEBCEVDUPSSFJOTFSUJPOUFDIOJRVFQSPWFEUPCF TJNQMFBOEFĊFDUJWF"MUIPVHITVSWJWBMPGUIFHSBGUXBTHPPE SFWJTJPOPG UIFTUFNXBTGSFRVFOUXIFODPNQBSFEUPPUIFSDPNQPTJUFUFDIOJRVFT8F DPOTJEFSFEUIFRVBMJUZPGUIFQSFTTmUmYBUJPOPGUIFTUFNJOUIFIPTU NPSF UIBOUIFVTFPGDFNFOUJOUIFHSBGU UIFLFZEFUFSNJOBOUPGMPOHFWJUZ )PXFWFS BTUFNmYBUFEJOUPUIFHSBGUXJUIPVUDFNFOUJTMJLFMZUPTVCTJEF PODFMPPTFOJOHPGUIFTUFNJOUIFIPTUIBTEFWFMPQFEɨFQJUGBMMPGPVS UFDIOJRVFJTUIFEJċDVMUZPGHFUUJOHBEFRVBUFQSFTTmUmYBUJPOPGUIFTUFN JOCPUIHSBGUBOEIPTUCPOF.

(5)

(6)

Referenties

GERELATEERDE DOCUMENTEN

Studies of the stellar composition, using optical and near-infrared broadband photometry, reinforced this picture of relatively low- mass, moderately star forming objects (Sawicki

2 Ultradeep NIR ISAAC observations of the HDF-South: observations, reduction, multicolor catalog, and photometric redshifts Furthermore, the predicted color correction is small

-A steep galaxy mass function at high redshift: if much of the U V light which is used to measure the SFR at high redshifts comes from small galaxies which would fall below

We focus on the galaxies that populate the blue peak of galaxies at low and high redshift. We wish to understand the nature of the blue color-magnitude relation, the evolution of

Figure 3 — The range in best-fit extinction and age values of various DRGs, for constant star forming models (Bruzual & Charlot 2003) including dust Calzetti et al (2000).. We

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/3765.

"SHFOUJOBɨFEFWFMPQNFOUPGCFUUFSUFDIOJRVFTGPSPTUFPTZOUIFTJTBMTP DPOUSJCVUFEUPUIFTFJNQSPWFEDMJOJDBMSFTVMUTɨFTVDDFTTGVMMPOHUFSN SFQPSUTCZ.BOLJO õ