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Nagel, H. T. C. (2007, February 14). Follow-up studies in prenatal medicine. Retrieved
from https://hdl.handle.net/1887/9762
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Follow-up studies in prenatal medicine
Hélène T.C. Nagel
Follow-up studies
in prenatal medicine
Proefschrift
ter verkrijging van
de graad van D octor aan de U niversiteit Leiden, op gezag van Rector M agnificus prof.m r P.F. van der H eijden,
volgens besluit van het College voor Prom oties te verdedigen op w oensdag 14 februari 2007
klokke 13.45 uur
door
H élène Theodora Catharina N agel geboren te Rijswijk
in 1968
Promotie commissie:
Promotor: Prof. Dr. H.H.H. Kanhai Co-promotor: Dr. F.P.H.A. Vandenbussche
Referent: Prof. Dr. F. Van Bel
(Universitair Medisch Centrum Utrecht) O verige leden: Prof. Dr. M.H. Breuning
Prof. Dr. A.A. Kaptein
Blackbird singing in the dead of night Take these broken wings and learn to fly All your life
You were only waiting for this moment to arise.
Blackbird singing in the dead of night Take these sunken eyes and learn to see All your life
You were only waiting for this moment to be free.
Blackbird fly Blackbird fly
Into the light of the dark black night.
(Lennon / McCartney)
Aan Lex
Contents
C H A P T E R 1 G eneral introduction 11
Studies on prenatal diagnosis
C H A P T E R 2 Prenatal diagnosis in the Netherlands, 1991-2000:
Number of invasive procedures, indications, abnormal results,
and terminations of pregnancy 21
C H A P T E R 3 Amniocentesis before 14 completed w eeks as an alternative to transabdominal chorionic villus sampling: a controlled trial
w ith infant follow -up 37
C H A P T E R 4 O utcome of children w ith prenatally diagnosed central nervous
system malformations 57
C H A P T E R 5 Follow -up of children born w ith an umblical arterial blood pH < 7 71
Studies on prenatal therapy
C H A P T E R 6 Long-term neurodevelopmental outcome in tw in-to-tw in
transfusion syndrome 85
C H A P T E R 7 Long-term outcome after fetal transfusion for hydrops
associated w ith parvovirus B19 infection 99
C H A P T E R 8 Fetal arrhythmia and long-term outcome 113
C H A P T E R 9 G eneral discussion 131
C H A P T E R 1 0 Summary / Samenvatting 139
Publications 155
Curriculum Vitae 161
Acknow ledgements 163
