Membrane fusion studies with solid state NMR : a new structural perspective on the interplay between biomimetic lipids and De Novo designed synthetic peptides

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded.

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded

and its use in a study directed towards the identification of novel targets of. organophosphate based nerve agents. The same probe is also used in

biological effects of the compounds and only one kinase significantly crosscorrelated:. PKB/Akt. Due to the efforts of the pharmaceutical industry and

potency and selectivity. Next, the synthetic strategy to the lead compound resulting from. this first library is adapted to allow larger quantities to

the involvement of activated PKB/Akt1 in bacterial infection and the development of. inhibitors against PKB/Akt1 are described. In short, Salmonella bacteria

different in nature and functioning, the bacterial cell is not that different from an. erythrocyte (GS induced lysis of which causes hemolysis) where it

acids. Replacing either the Pro – DTyr or the AspTrp motif resulted in analogues (7 – 10). with defined secondary structures that could be analyzed based