Cover Page

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Cover Page

The handle http://hdl.handle.net/1887/61048 holds various files of this Leiden University dissertation

Author: Koppen, Hille

Title: Migraine, the heart and the brain

Date: 2018-02-15

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Migraine, the heart and the brain

Hille Koppen

42210 Hille Koppen.indd 1 21-12-17 09:35

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Migraine, the heart and the brain.

PhD thesis: Leiden University Medical Center, Leiden 2018

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior written permission from the copyright owner.

Lay-out by Ferdinand van Nispen, my-thesis.nl Printed by GVO drukkers en vormgevers B.V.s ISBN: 978-94-6332-309-3

Financial support for the printing of this thesis was provided by: Nederlandse

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Migraine, the heart and the brain

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden op gezag van Rector Magnificus

Prof.mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op donderdag 15 februari 2018

klokke 16.15 uur

door Hille Koppen geboren te Eindhoven in 1975

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Promotor: Prof. dr. M.D. Ferrari

Co-promotores: Dr. G.M. Terwindt Dr. M.C. Kruit

Leden promotiecommissie:

Dr. S.F.T.M. de Bruijn, HagaZiekenhuis

Dr. L.J. Launer, National Institute on Aging, Bethesda, VS Prof. dr. A. de Roos

Prof. dr. F.R. Rosendaal

Prof. dr. C.I. de Zeeuw, Erasmus MC

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C

^ONTENT

Chapter 1 Introduction 9

Part 1 Migraine and brain imaging 25

Chapter 2 Structural Brain Changes in Migraine 27

Part 2 Migraine and the heart 53

Chapter 3 Systemic right-to-left shunts, ischemic brain lesions, and persistent migraine activity

55

Chapter 4 Right-to-left shunts and micro-embolization in migraine 73 Chapter 5 Aortic root pathology in Marfan syndrome increases the risk of

migraine with aura

85

Chapter 6 Cardiac monitoring of high dose verapamil in cluster headache - An international Delphi study

97

Part 3 Migraine and brain function 111

Chapter 7 Cerebellar function and ischemic brain lesions in migraine patients from the general population

113

Chapter 8 The impact of a migraine attack and its after-effects on perceptual organization, attention, and working memory

143

Chapter 9 Summary and general discussion 161

Nederlandse samenvatting en discussie 175

Dankwoord 181

Curriculum Vitae 183

List of publications 184