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59% 58% 57% 57% 57% 56% 56% 0 1000 2000 3000 4000 5000 6000 7000 8000 1/2010 1/2012 1/2014 1/2015 1/2016 1/2017 1/2018 1/2019 on dialysis 7304 7701 7911 8075 8087 8138 8249 8333 transplanted 5142 5605 5939 6058 6153 6349 6548 6671

Total number patients on Renal

Replacement Therapy on 1 January 12446 13306 13850 14133 14240 14487 14797 15004

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0 500 1000 1500 2000 2500 18-24 25-34 35-44 45-54 55-64 65-74 75-84 >=85 dialysis 53 159 341 651 1180 2168 2565 1215 transplantation 63 323 664 1230 1866 1801 617 106

% transplant patientsper age-group 54% 67% 66% 65% 61% 45% 19% 8%

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65% 66% 67% 66% 65% 64% 60% 60% 26% 25% 25% 26% 27% 28% 32% 33% 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 1/2010 1/2012 1/2014 1/2015 1/2016 1/2017 1/2018 1/2019 Peritoneal dialysis 689 672 641 639 621 614 617 616

Hemodialysis - Low Care 1878 1919 1967 2127 2180 2306 2657 2732

Hemodialysis - High Care 4737 5110 5303 5309 5286 5218 4973 4985

Total number patients in dialysis

on 1 January 7304 7701 7911 8075 8087 8138 8247 8333

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1200 1300 1400 1500 1600 1700 1800 1900 2000 2100 1-12 / 2009 1-12 / 2011 1-12 / 2013 1-12 / 2014 1-12 / 2015 1-12 / 2016 1-12 / 2017 1-12 / 2018

first start RRT with transplantation 22 44 43 45 33 40 56 21

first start RRT on dialysis 2131 1985 2014 1937 2019 2047 2058 2105

Inflow on Renal Replacement Therapy per year

Total number patients – first start on dialysis

% difference per year – first start on HD or PD

2131 1985 2014 1937 -4% 2019 +4% 2047 +1% 2058 +0,5% 2105 +2%

Collège de médecins

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0 200 400 600 800 1000 1200 1400 1-12 / 2009 1-12 / 2011 1-12 / 2013 1-12 / 2014 1-12 / 2015 1-12 / 2016 1-12 / 2017 1-12 / 2018 Outflow by transplantation 455 468 458 436 495 480 485 473 Outflow by death 1482 1427 1464 1390 1466 1548 1499 1491

Outflow on dialysis per year

Mortality per 100 patient years 17,7 16,4 16,4 15,4 16,1 16,9 16,2 15,9

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Survival analysis : patient survival of dialysis patients & kidney graft survival in transplant patients (deceased

and living donor) - comparison of different cohorts

Analysis made by the ERA-EDTA registry

Collège de médecins

30 40 50 60 70 80 90 100 0 1 2 3 4 5 P e rcen ta ge p ati e n t su rviv al w h ile on d ia ly si s

years after start dialysis

cohort 2006-2010 cohort 2008-2012 cohort 2011-2015 30 40 50 60 70 80 90 100 0 1 2 3 4 5 P e rcen ta ge g ra ft su rviv al a ft er tr an sp la n ta ti on

years after transplantation

deceased donor - cohort 2008-2012 deceased donor - cohort 2011-2015 living donor - cohort 2008-2012 living donor - cohort 2011-2015

Kaplan Meier method Kaplan Meier method

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Survival analysis : patient survival of dialysis patients & kidney graft survival in transplant patients (deceased

donor) - comparison of different cohorts

Analysis made by the ERA-EDTA registry

Collège de médecins

30 40 50 60 70 80 90 100 0 1 2 3 4 5 P erce n tage p atient sur vival whil e o n d ial ysis

years after start dialysis

DM - cohort 2008-2012 DM - cohort 2011-2015 30 40 50 60 70 80 90 100 0 1 2 3 4 5 P erce n tage graft sur vival after tran spl an tat io n

years after transplantation

DM - deceased donor - cohort 2008-2012 DM - deceased donor - cohort 2011-2015

renal disease = diabetic nephropathy Kaplan Meier method

renal disease = diabetic nephropathy Kaplan Meier method

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Expected remaining lifetime (years) for general population, patients on dialysis & patients living with a

transplant - Belgium

Analysis made by the ERA-EDTA registry

Referenties

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