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Psychotropic medications and the developing brain
Solleveld, M.M.
Publication date
2018
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Solleveld, M. M. (2018). Psychotropic medications and the developing brain.
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Psychotropic medications
and the developing brain
Michelle
Solleveld
UITNODIGING
voor het bijwonen
van de openbare
verdediging van
mijn proefschrift
Psychotropic
medications
and the
developing
brain
Woensdag 17 januari 2018
om 10:00 uur
Agnietenkapel van de
Universiteit van Amsterdam
Oudezijds Voorburgwal 231
te Amsterdam
Michelle Solleveld
michellemsolleveld@gmail.com
Paranimfen:
Claudia Vingerhoets
Geor Bakker
promotiemichelle@gmail.comPsychotropic medications and the developing brain
Psychotropic medications
and the developing brain
Copyright © M.M. Solleveld, Amsterdam, 2017
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without prior permission in writing of the author.
The research in this thesis was supported by faculty resources of the University of Amsterdam including an Amsterdam Brain and Cognition grant, as well as an ERA-NET PrioMedChild FP-6 (EU), grant number 11.32050.226. Funding resources were not involved in the content of this thesis.
ISBN: 9789462958067
Cover design: Michelle Solleveld
Psychotropic medications
and the developing brain
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op woensdag 17 januari 2018, te 10:00 uur
door Michelle Marissa Solleveld geboren te Soest
Promotie commissie:
Promotores: prof. dr. P.J. Lucassen Universiteit van Amsterdam
prof. dr. L. Reneman Universiteit van Amsterdam
Copromotor: dr. A.G.M. Schrantee Universiteit van Amsterdam
Overige leden: prof. dr. F. Boer Universiteit van Amsterdam
prof. dr. J. Booij Universiteit van Amsterdam
prof. dr. J.H. van Maarseveen Universiteit van Amsterdam
prof. dr. D.F. Swaab Universiteit van Amsterdam
dr. J.R. Homberg Radboud Universiteit van
Nijmegen
PSYCHOTROPIC MEDICATIONS AND THE DEVELOPING BRAIN
Chapter 1 General introduction and thesis outline 7
PART I Attention-Deficit/Hyperactivity Disorder
Chapter 2 Age-dependent, lasting effects of methylphenidate on the 21
GABAergic system of ADHD patients
Chapter 3 Age-dependent effects of methylphenidate on emotion 41
regulation and impulsivity: a randomized controlled trial in stimulant treatment-naive patients with ADHD
Chapter 4 Positive effects of prolonged methylphenidate treatment on 67
sleep in children with Attention-Deficit/Hyperactivity Disorder: a double-blind randomized controlled trial
PART II Major Depressive Disorder
Chapter 5 Non-invasive MR assessment of serotonin function: 93
dose-dependent effects of the SSRI citalopram
Chapter 6 A pharmacological MRI study on the effects of selective 109
serotonin reuptake inhibitors on the human serotonergic system: modulation by age of first use
PART III Summary, general discussion and conclusions
Chapter 7 English summary, general discussion and conclusions 129
Chapter 8 Dutch Summary | Nederlandse samenvatting 147
PART IV Appendices
List of publications & PhD portfolio 153
Acknowledgements | Dankwoord 155
