Green Extraction, Fractionation, Micronization
plant components
Professorship Biorefinery
• Professorship biorefinery has three major research themes:
• Green extraction
• Green fractionation/purification • Green micronization
• GREEN = APPLICATION BIOBASED RENEWABLE SOLVENTS • Water, CO2, bio-ethanol and natural deep eutectic solvents
Biomass value pyramid: biocascading
➢ Using all the
components from biomass for value creation
➢ Implementation of
cost effective energy efficient green biorefinery processes ➢ Industrial symbiosis for complete biomass valorisation
Greenextraction
• Greenextraction are extraction processes which reduces
energy consumption, makes use of renewable solvents, and ensure a safe high quality product. (Chemat et al 2015)
• Natural ingredients
(secondary plant metabolites) sourced from botanicals,
existing crops/marines or side streams of biomass
Greenextraction scCO2 from labscale….
• Process development on lab scale
– Extraction Pmax 1000bar, Tmax 250C – Cosolvent Pmax 400bar
to upscale by simulation …..
• Process development on lab scale • Process simulation in
– ASPEN (process simulation) and – SuperPro Designer (Cost simulation) • Process optimisation on semi-industrial
To semi-industrial scale in
H2020 project LIBBIO …
lupin biorefinery • H2020 project, 14 partners 8 countries • Hanze is techno-scientific coordinator • Hanze develops integrated scCO2 biorefineryThis project has received funding from the Bio Based Industries Joint Undertaking under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 720726.
Greenextraction
• Cooperation with many SME’s – SynCom – DonkerGroen – AVEBE – Ofichem – HLB– New Business AgriFood – Feyecon
– Chemconnection
• Initiation of Phytosana in cooperation with RUG
Natural Deep Eutectic Solvent Extraction
NADES
• Deep Eutectic Solvents are mixtures from two or more components from hydrogen bond donors (HBD) and
hydrogen bond acceptors (HBA) creating compound specific intermolecular “holes” by hydrogen bridges and van der Waals forces between molecules.
• Deep Eutectic Solvents are typically blends with melting points much lower than that of individual components. • These mixtures have low vapour
pressure, large solvency, low toxicity and high biodegradability.
• Tailor-made hydrophilic or hydrophobic DES’s can be designed for extraction of different categories of bioactive
ingredients such as polyphenolics, carotenoids, polysaccharides
• DES are low in costs of synthesis and utilisation
NADES principle
Principle of DES extraction: Selected Hydrogen Bond Donor and Hydrogen Bond Acceptor are mixed in specific ratios for creating specific steric intermolecular “holes” for attracting specific compounds in liquid or liquid-solid extraction processes
Xu et al 2015, A green deep eutectic solvent-based aqueous two-phase system for protein extracting
NADES simulation
Molecular structure and charge density of Triethylene Glycol (TEG) and Choline Chloride (ChCl) and the combined DES. Image from Aissaoui et al 2017, Theoretical investigation on the microstructure of tri-ethylene glycol based deep eutectic solvents: COSMO-RS and TURBOMOLE prediction.
Supercritical Particle Formation micronization
• RESS: Rapid Expansion of supercritical Solutes (=SFN Supercritical fluid nucleation) • SAS: Super Critical AntiSolvent methodSupercritical Particle Formation micronization
Schematic drawing and image of Supercritical Anti Solvent (SAS) particle formation system for protein back-extraction and supercritical assisted spraydrying T-mixer design in different possible configurations for supercritical assisted spray-drying with NADES protein solutions and ethanol and/or water
