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The role of intracellular thyroid hormone metabolism in innate immune cells

van der Spek, A.H.

Publication date

2018

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Citation for published version (APA):

van der Spek, A. H. (2018). The role of intracellular thyroid hormone metabolism in innate

immune cells.

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STELLINGEN BEHORENDE BIJ HET PROEFSCHRIFT

The Role of Intracellular Thyroid Hormone Metabolism in Innate Immune Cells

1. Strikte regulatie van intracellulaire schildklierhormoonconcentraties is essentieel voor de functie van neutrofielen en macrofagen. Dit proefschrift

2. Neutrofielen functioneren beter bij lage intracellulaire schildklierhormoon concentraties. Dit proefschrift

3. Type 2 deiodase is van belang voor de pro-inflammatoire functie van macrofagen. Dit proefschrift

4. Neutrofielen, monocyten en hun gezamenlijke voorlopers hebben een verschillend intracellulair schildklierhormoon metabolisme. Dit proefschrift 5. Patiënten met schildklierhormoon resistentie door een mutatie in de

schildklierhormoon receptor α hebben verhoogde interleukine-8 concentraties in het bloed. Dit proefschrift

6. Het blokkeren van de schildklierhormoon receptor α in de macrofaag beïnvloedt het fenotype. Dit proefschrift

7. Je moet weten hoe iets functioneert om erachter te komen hoe het mis kan gaan. Dick Swaab over fundamenteel onderzoek; Volkskrant, 24-09-2016 8. We must take things as they really are, and not as we wish them to be.

Rudolph Virchow

9. Wetenschappelijke samenwerking tussen verschillende disciplines en instituten tilt, meer dan wetenschappelijke concurrentie, het eindresultaat naar een hoger niveau.

10. Er zou minder nadruk moeten liggen op het voltooien van een promotieonderzoek als voorwaarde voor toelating tot een medische specialisatie.

11. Nothing will work unless you do. Maya Angelou

12. In basic science, many things won’t work even if you do, and when they suddenly do you won’t understand why.

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