Optimising diagnosis and treatment of coagulopathy in severely injured trauma patients - Front matter

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Optimising diagnosis and treatment of coagulopathy in severely injured trauma

patients

Balvers, K.

Publication date

2016

Document Version

Final published version

Link to publication

Citation for published version (APA):

Balvers, K. (2016). Optimising diagnosis and treatment of coagulopathy in severely injured

trauma patients.

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OPTIMISING DIAGNOSIS AND TREATMENT OF

COAGULOPATHY IN SEVERELY INJURED

TRAUMA PATIENTS

Kirsten Balvers

TMENT OF COAGULOP A THY IN SEVEREL Y INJURED TRAUMA P A TIENTS KIRSTEN BAL VERS

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OPTIMISING DIAGNOSIS AND TREATMENT OF

COAGULOPATHY IN SEVERELY INJURED

TRAUMA PATIENTS

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ISBN: 978-94-028-0202-3

Cover design and layout: Susan Hatzmann Printed by: Ipskamp Printing

The copyright of the published and accepted articles has been transferred to the respective publishers. No part of this thesis may be reproduced, stored or transmitted, in any form or by any means, without permission of the author.

The printing of this thesis was financially supported by: Tem International GmbH, CSL Behring, Nederlandse Vereniging voor Traumachirurgie, TraumaNet AMC, Wetenschappelijk Fonds Chirurgie AMC, Academisch Medisch Centrum (AMC), ABN AMRO, Chipsoft B.V.

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OPTIMISING DIAGNOSIS AND TREATMENT OF

COAGULOPATHY IN SEVERELY INJURED

TRAUMA PATIENTS

ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor

aan de Universiteit van Amsterdam op gezag van de Rector Magnificus

prof. dr. D.C. van den Boom

ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel

op vrijdag 24 juni 2016, te 14:00 uur door Kirsten Balvers

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Co-promotor: Prof. dr. N.P. Juffermans Universiteit van Amsterdam

Overige leden: Prof. dr. C. Boer Vrije Universiteit Amsterdam Dr. S.S. Zeerleder Universiteit van Amsterdam Prof. dr. M.J. Schultz Universiteit van Amsterdam Prof. dr. L.P.H. Leenen Universiteit Utrecht

Prof. dr. M.W. Hollmann Universiteit van Amsterdam Prof. dr. K. Brohi Queen Mary University of London Faculteit der Geneeskunde

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CONTENTS

General introduction and outline of the thesis PART 1 DIAGNOSIS

Chapter 1 The utility of thromboelastometry (ROTEM®_{) and}

thromboelastography (TEG®_{) to detect coagulation disorders}

in non-bleeding ICU patients

Chapter 2 Thromboelastometry and organ failure in trauma patients: a prospective cohort study

Chapter 3 Haemoglobin level and neurologic outcome in patients with severe traumatic brain injury

Chapter 4 Endogenous microparticles drive the pro-inflammatory host immune response in severely injured trauma patients

PART 2 TREATMENT

Chapter 5 Risk factors related to trauma-induced coagulopathy and resuscitation strategies for the development of multiple organ failure in severely injured trauma patients

Chapter 6 Is hypothermia at ICU admission an independent predictor of 28-days mortality?

Chapter 7 Effects of implementation of a massive transfusion protocol on the usage of blood products and transfusion strategies

Chapter 8 Are there any alternatives for transfusion of AB plasma as universal donor in an emergency release setting?

Chapter 9 Therapeutic strategies associated with improved outcomes in bleeding trauma patients

Chapter 10 Transfusion strategy associated with correction of coagulopathy as detected by ROTEM®_{in bleeding trauma}

patients 9 23 35 51 63 77 103 119 135 149 169

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Dankwoord Curriculum Vitae

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