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The role of intracellular thyroid hormone metabolism in innate immune cells

van der Spek, A.H.

Publication date

2018

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Other version

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Citation for published version (APA):

van der Spek, A. H. (2018). The role of intracellular thyroid hormone metabolism in innate

immune cells.

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The role of

INTRACELLULAR

THYROID

HORMONE

METABOLISM

in

INNATE IMMUNE CELLS

Anne H. van der Spek

Th

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m

on

e a

nd i

nn

ate i

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m

un

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A

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e H

. v

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pe

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The role of

INTRACELLULAR

THYROID

HORMONE

METABOLISM

in

INNATE IMMUNE CELLS

Anne H. van der Spek

Th

yr

oid h

or

m

on

e a

nd i

nn

ate i

m

m

un

e c

ells

A

nn

e H

. v

an d

er S

pe

k

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Processed on: 16-5-2018 PDF page: 2PDF page: 2PDF page: 2PDF page: 2

The Role of Intracellular

Thyroid Hormone Metabolism in

Innate Immune Cells

Anne H. van der Spek

516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018

Processed on: 16-5-2018 PDF page: 3PDF page: 3PDF page: 3PDF page: 3

The Role of Intracellular

Thyroid Hormone Metabolism in

Innate Immune Cells

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Processed on: 16-5-2018 PDF page: 2PDF page: 2PDF page: 2PDF page: 2

The Role of Intracellular

Thyroid Hormone Metabolism in

Innate Immune Cells

Anne H. van der Spek

516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018

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The Role of Intracellular

Thyroid Hormone Metabolism in

Innate Immune Cells

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Processed on: 16-5-2018 PDF page: 4PDF page: 4PDF page: 4PDF page: 4

ISBN

978-94-028-0980-0

Artwork and Graphic Design

Lydia van der Spek

Design/Lay-out

Wendy Bour-van Telgen, Ipskamp Printing Enschede

Print

Ipskamp Printing, Enschede

The research described in this thesis was financially supported by the AMC Graduate School

PhD Scholarship and the AMC Foundation

The printing of this thesis was financially supported by Ipsen Farmaceutica B.V. and Goodlife.

© Anne Helene van der Spek, 2018

All rights are reserved. No part of this book may be reproduced, distributed, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.

The Role of Intracellular

Thyroid Hormone Metabolism in

Innate Immune Cells

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel

op woensdag 27 juni 2018, te 12:00 uur

door

Anne Helene van der Spek

geboren te Londen, Verenigd Koninkrijk

516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018

Processed on: 16-5-2018 PDF page: 5PDF page: 5PDF page: 5PDF page: 5

The Role of Intracellular

Thyroid Hormone Metabolism in

Innate Immune Cells

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam

op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel

op woensdag 27 juni 2018, te 12:00 uur

door

Anne Helene van der Spek

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516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018

Processed on: 16-5-2018 PDF page: 4PDF page: 4PDF page: 4PDF page: 4

ISBN

978-94-028-0980-0

Artwork and Graphic Design

Lydia van der Spek

Design/Lay-out

Wendy Bour-van Telgen, Ipskamp Printing Enschede

Print

Ipskamp Printing, Enschede

The research described in this thesis was financially supported by the AMC Graduate School

PhD Scholarship and the AMC Foundation

The printing of this thesis was financially supported by Ipsen Farmaceutica B.V. and Goodlife.

© Anne Helene van der Spek, 2018

All rights are reserved. No part of this book may be reproduced, distributed, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.

The Role of Intracellular

Thyroid Hormone Metabolism in

Innate Immune Cells

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel

op woensdag 27 juni 2018, te 12:00 uur

door

Anne Helene van der Spek

geboren te Londen, Verenigd Koninkrijk

516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018

Processed on: 16-5-2018 PDF page: 5PDF page: 5PDF page: 5PDF page: 5

The Role of Intracellular

Thyroid Hormone Metabolism in

Innate Immune Cells

ACADEMISCH PROEFSCHRIFT

ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus

prof. dr. ir. K.I.J. Maex

ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel

op woensdag 27 juni 2018, te 12:00 uur

door

Anne Helene van der Spek

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Processed on: 16-5-2018 PDF page: 6PDF page: 6PDF page: 6PDF page: 6

Promotiecommissie:

Promotor: prof.dr. E. Fliers AMC-UvA

Copromotor: dr. A. Boelen AMC-UvA

Overige leden: prof. dr. J.A. Romijn AMC-UvA

dr. W.S. Simonides Vrije Universiteit Amsterdam prof. dr. W.J. Wiersinga AMC-UvA

prof.dr.ir. T.J. Visser† Erasmus Universiteit Rotterdam prof. dr. T.K. van den Berg Vrije Universiteit Amsterdam prof. dr. N.P. Juffermans AMC-UvA

Faculteit: Geneeskunde 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018

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Processed on: 16-5-2018 PDF page: 6PDF page: 6PDF page: 6PDF page: 6

Promotiecommissie:

Promotor: prof.dr. E. Fliers AMC-UvA

Copromotor: dr. A. Boelen AMC-UvA

Overige leden: prof. dr. J.A. Romijn AMC-UvA

dr. W.S. Simonides Vrije Universiteit Amsterdam prof. dr. W.J. Wiersinga AMC-UvA

prof.dr.ir. T.J. Visser† Erasmus Universiteit Rotterdam prof. dr. T.K. van den Berg Vrije Universiteit Amsterdam prof. dr. N.P. Juffermans AMC-UvA

Faculteit: Geneeskunde 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018

Processed on: 16-5-2018 PDF page: 7PDF page: 7PDF page: 7PDF page: 7

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Table of Contents

Chapter 1: General Introduction

Molecular and Cellular Endocrinology, 2017 Dec 15;458:29-38.

Journal of Endocrinology, 2017 Feb;232(2):R67-R81

Chapter 2: Intracellular Thyroid Hormone Metabolism in Neutrophils and Monocytes

Part I: Thyroid hormone metabolism and neutrophil function

Chapter 3: The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils

Endocrinology 2016 Aug;157(8):3293-305

Chapter 4: ATRA-differentiated NB4 cells: an in vitro model for the study of D3 in human neutrophils

Chapter 5: The Thyroid Hormone Inactivating Type 3 Deiodinase is Essential for Optimal Neutrophil Function - observations from 3 species

Endocrinology 2018 Feb 1;159(2):826-835

Part II: Thyroid hormone metabolism and macrophage function

Chapter 6: Increased Circulating Interleukin-8 in Patients with Resistance to Thyroid Hormone Receptor α

Endocrine Connections; 2017 Nov;6(8):731-740

Chapter 7: Regulation of Intracellular Triiodothyronine is Essential for Optimal Macrophage Function

Manuscript accepted

Chapter 8: General discussion

Journal of Endocrinology, 2017 Feb;232(2):R67-R81

References

Appendix Summary, Nederlandstalige samenvatting, Author and Affiliations,

Publications in this thesis, PhD portfolio, About the Author, Acknowledgments 10 22 33 34 58 70 87 88 104 126 138 156

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Processed on: 16-5-2018 PDF page: 9PDF page: 9PDF page: 9PDF page: 9

Table of Contents

Chapter 1: General Introduction

Molecular and Cellular Endocrinology, 2017 Dec 15;458:29-38.

Journal of Endocrinology, 2017 Feb;232(2):R67-R81

Chapter 2: Intracellular Thyroid Hormone Metabolism in Neutrophils and Monocytes

Part I: Thyroid hormone metabolism and neutrophil function

Chapter 3: The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils

Endocrinology 2016 Aug;157(8):3293-305

Chapter 4: ATRA-differentiated NB4 cells: an in vitro model for the study of D3 in human neutrophils

Chapter 5: The Thyroid Hormone Inactivating Type 3 Deiodinase is Essential for Optimal Neutrophil Function - observations from 3 species

Endocrinology 2018 Feb 1;159(2):826-835

Part II: Thyroid hormone metabolism and macrophage function

Chapter 6: Increased Circulating Interleukin-8 in Patients with Resistance to Thyroid Hormone Receptor α

Endocrine Connections; 2017 Nov;6(8):731-740

Chapter 7: Regulation of Intracellular Triiodothyronine is Essential for Optimal Macrophage Function

Manuscript accepted

Chapter 8: General discussion

Journal of Endocrinology, 2017 Feb;232(2):R67-R81

References

Appendix Summary, Nederlandstalige samenvatting, Author and Affiliations,

Publications in this thesis, PhD portfolio, About the Author, Acknowledgments 10 22 33 34 58 70 87 88 104 126 138 156

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