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The role of intracellular thyroid hormone metabolism in innate immune cells
van der Spek, A.H.
Publication date
2018
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Citation for published version (APA):
van der Spek, A. H. (2018). The role of intracellular thyroid hormone metabolism in innate
immune cells.
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The role of
INTRACELLULAR
THYROID
HORMONE
METABOLISM
in
INNATE IMMUNE CELLS
Anne H. van der Spek
Th
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m
on
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nd i
nn
ate i
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m
un
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A
nn
e H
. v
an d
er S
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k
The role of
INTRACELLULAR
THYROID
HORMONE
METABOLISM
in
INNATE IMMUNE CELLS
Anne H. van der Spek
Th
yr
oid h
or
m
on
e a
nd i
nn
ate i
m
m
un
e c
ells
A
nn
e H
. v
an d
er S
pe
k
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 2PDF page: 2PDF page: 2PDF page: 2
The Role of Intracellular
Thyroid Hormone Metabolism in
Innate Immune Cells
Anne H. van der Spek
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 3PDF page: 3PDF page: 3PDF page: 3
The Role of Intracellular
Thyroid Hormone Metabolism in
Innate Immune Cells
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 2PDF page: 2PDF page: 2PDF page: 2
The Role of Intracellular
Thyroid Hormone Metabolism in
Innate Immune Cells
Anne H. van der Spek
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 3PDF page: 3PDF page: 3PDF page: 3
The Role of Intracellular
Thyroid Hormone Metabolism in
Innate Immune Cells
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 4PDF page: 4PDF page: 4PDF page: 4
ISBN
978-94-028-0980-0
Artwork and Graphic Design
Lydia van der Spek
Design/Lay-out
Wendy Bour-van Telgen, Ipskamp Printing Enschede
Ipskamp Printing, Enschede
The research described in this thesis was financially supported by the AMC Graduate School
PhD Scholarship and the AMC Foundation
The printing of this thesis was financially supported by Ipsen Farmaceutica B.V. and Goodlife.
© Anne Helene van der Spek, 2018
All rights are reserved. No part of this book may be reproduced, distributed, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
The Role of Intracellular
Thyroid Hormone Metabolism in
Innate Immune Cells
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op woensdag 27 juni 2018, te 12:00 uur
door
Anne Helene van der Spek
geboren te Londen, Verenigd Koninkrijk
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 5PDF page: 5PDF page: 5PDF page: 5
The Role of Intracellular
Thyroid Hormone Metabolism in
Innate Immune Cells
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam
op gezag van de Rector Magnificus prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op woensdag 27 juni 2018, te 12:00 uur
door
Anne Helene van der Spek
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 4PDF page: 4PDF page: 4PDF page: 4
ISBN
978-94-028-0980-0
Artwork and Graphic Design
Lydia van der Spek
Design/Lay-out
Wendy Bour-van Telgen, Ipskamp Printing Enschede
Ipskamp Printing, Enschede
The research described in this thesis was financially supported by the AMC Graduate School
PhD Scholarship and the AMC Foundation
The printing of this thesis was financially supported by Ipsen Farmaceutica B.V. and Goodlife.
© Anne Helene van der Spek, 2018
All rights are reserved. No part of this book may be reproduced, distributed, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
The Role of Intracellular
Thyroid Hormone Metabolism in
Innate Immune Cells
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op woensdag 27 juni 2018, te 12:00 uur
door
Anne Helene van der Spek
geboren te Londen, Verenigd Koninkrijk
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 5PDF page: 5PDF page: 5PDF page: 5
The Role of Intracellular
Thyroid Hormone Metabolism in
Innate Immune Cells
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op woensdag 27 juni 2018, te 12:00 uur
door
Anne Helene van der Spek
516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
Processed on: 16-5-2018 PDF page: 6PDF page: 6PDF page: 6PDF page: 6
Promotiecommissie:
Promotor: prof.dr. E. Fliers AMC-UvA
Copromotor: dr. A. Boelen AMC-UvA
Overige leden: prof. dr. J.A. Romijn AMC-UvA
dr. W.S. Simonides Vrije Universiteit Amsterdam prof. dr. W.J. Wiersinga AMC-UvA
prof.dr.ir. T.J. Visser† Erasmus Universiteit Rotterdam prof. dr. T.K. van den Berg Vrije Universiteit Amsterdam prof. dr. N.P. Juffermans AMC-UvA
Faculteit: Geneeskunde 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
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Processed on: 16-5-2018 PDF page: 6PDF page: 6PDF page: 6PDF page: 6
Promotiecommissie:
Promotor: prof.dr. E. Fliers AMC-UvA
Copromotor: dr. A. Boelen AMC-UvA
Overige leden: prof. dr. J.A. Romijn AMC-UvA
dr. W.S. Simonides Vrije Universiteit Amsterdam prof. dr. W.J. Wiersinga AMC-UvA
prof.dr.ir. T.J. Visser† Erasmus Universiteit Rotterdam prof. dr. T.K. van den Berg Vrije Universiteit Amsterdam prof. dr. N.P. Juffermans AMC-UvA
Faculteit: Geneeskunde 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek 516644-L-bw-spek Processed on: 16-5-2018 Processed on: 16-5-2018 Processed on: 16-5-2018
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Table of Contents
Chapter 1: General Introduction
Molecular and Cellular Endocrinology, 2017 Dec 15;458:29-38.
Journal of Endocrinology, 2017 Feb;232(2):R67-R81
Chapter 2: Intracellular Thyroid Hormone Metabolism in Neutrophils and Monocytes
Part I: Thyroid hormone metabolism and neutrophil function
Chapter 3: The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils
Endocrinology 2016 Aug;157(8):3293-305
Chapter 4: ATRA-differentiated NB4 cells: an in vitro model for the study of D3 in human neutrophils
Chapter 5: The Thyroid Hormone Inactivating Type 3 Deiodinase is Essential for Optimal Neutrophil Function - observations from 3 species
Endocrinology 2018 Feb 1;159(2):826-835
Part II: Thyroid hormone metabolism and macrophage function
Chapter 6: Increased Circulating Interleukin-8 in Patients with Resistance to Thyroid Hormone Receptor α
Endocrine Connections; 2017 Nov;6(8):731-740
Chapter 7: Regulation of Intracellular Triiodothyronine is Essential for Optimal Macrophage Function
Manuscript accepted
Chapter 8: General discussion
Journal of Endocrinology, 2017 Feb;232(2):R67-R81
References
Appendix Summary, Nederlandstalige samenvatting, Author and Affiliations,
Publications in this thesis, PhD portfolio, About the Author, Acknowledgments 10 22 33 34 58 70 87 88 104 126 138 156
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Processed on: 16-5-2018 PDF page: 9PDF page: 9PDF page: 9PDF page: 9
Table of Contents
Chapter 1: General Introduction
Molecular and Cellular Endocrinology, 2017 Dec 15;458:29-38.
Journal of Endocrinology, 2017 Feb;232(2):R67-R81
Chapter 2: Intracellular Thyroid Hormone Metabolism in Neutrophils and Monocytes
Part I: Thyroid hormone metabolism and neutrophil function
Chapter 3: The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils
Endocrinology 2016 Aug;157(8):3293-305
Chapter 4: ATRA-differentiated NB4 cells: an in vitro model for the study of D3 in human neutrophils
Chapter 5: The Thyroid Hormone Inactivating Type 3 Deiodinase is Essential for Optimal Neutrophil Function - observations from 3 species
Endocrinology 2018 Feb 1;159(2):826-835
Part II: Thyroid hormone metabolism and macrophage function
Chapter 6: Increased Circulating Interleukin-8 in Patients with Resistance to Thyroid Hormone Receptor α
Endocrine Connections; 2017 Nov;6(8):731-740
Chapter 7: Regulation of Intracellular Triiodothyronine is Essential for Optimal Macrophage Function
Manuscript accepted
Chapter 8: General discussion
Journal of Endocrinology, 2017 Feb;232(2):R67-R81
References
Appendix Summary, Nederlandstalige samenvatting, Author and Affiliations,
Publications in this thesis, PhD portfolio, About the Author, Acknowledgments 10 22 33 34 58 70 87 88 104 126 138 156